(1R,5S,6R)-6-ethynyl-3-azabicyclo[3.1.0]hexane hydrochloride | 2427583-96-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (1R,5S,6R)-6-ethynyl-3-azabicyclo[3.1.0]hexane hydrochloride
• 英文别名: (1R,5S)-6-ethynyl-3-azabicyclo[3.1.0]hexane;hydrochloride
• CAS: 2427583-96-6
• 化学式: C7H10ClN
• 分子量: 143.61
• InChiKey: GCKYDXZKJXIYBA-FXFNDYDPSA-N

文献信息

• NOVEL IMIDAZOLE DERIVATIVE
  申请人：Taisho Pharmaceutical Co., Ltd.

  公开号：EP3884940A1

  公开（公告）日：2021-09-29

  The present invention provides a new imidazole derivative represented by the following formula or a pharmaceutically acceptable salt thereof which exhibits potent antimicrobial activity based on a LpxC-inhibiting action against gram-negative bacteria such as Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumoniae, and their drug-resistant strains.

  本发明提供了一种由下式表示的新咪唑衍生物或其药学上可接受的盐，该衍生物具有基于 LpxC 抑制作用的强效抗菌活性，可对抗革兰氏阴性菌，如铜绿假单胞菌、大肠埃希菌和肺炎克雷伯菌及其耐药菌株。