5-[4-[[(2-Amino-4-pyridinyl)methyl]sulfonyl]-1-piperazinyl]-2-(3-chlorophenyl)-4-[(1-methylcyclopropyl)methoxy]-3(2H)-pyridazinone | 1062069-29-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 5-[4-[[(2-Amino-4-pyridinyl)methyl]sulfonyl]-1-piperazinyl]-2-(3-chlorophenyl)-4-[(1-methylcyclopropyl)methoxy]-3(2H)-pyridazinone
• 英文别名: 5-[4-[(2-aminopyridin-4-yl)methylsulfonyl]piperazin-1-yl]-2-(3-chlorophenyl)-4-[(1-methylcyclopropyl)methoxy]pyridazin-3-one
• CAS: 1062069-29-7
• 化学式: C₂₅H₂₉ClN₆O₄S
• 分子量: 545.1
• InChiKey: FLMWMIJTURMTQH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  37
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  130
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• Pyridazinone Derivatives Useful as Glucan Synthase Inhibitors
  申请人：Ting Pauline C.

  公开号：US20090170861A1

  公开（公告）日：2009-07-02

  In its many embodiments, the present invention provides -substituted pyridazinone compounds as glucan synthase inhibitors, methods of preparing such compounds, pharmaceutical including one or more of such compounds, methods of preparing pharmaceutical formulations including one or more such compounds or one or more such compounds along with other antifungal agents, and methods of treatment, prevention, inhibition, or amelioration of one or more fungal infections associated with glucan synthase using such compounds or pharmaceutical compositions.

  在其多种实施方式中，本发明提供了取代的吡啶嗪酮化合物作为葡聚糖合成酶抑制剂，制备这种化合物的方法，包括一种或多种这种化合物的制药物，制备包括一种或多种这种化合物或一种或多种这种化合物与其他抗真菌药物共同使用的制药配方的方法，以及使用这种化合物或制药组合物治疗、预防、抑制或改善与葡聚糖合成酶相关的一种或多种真菌感染的方法。
• US8232274B2
  申请人：——

  公开号：US8232274B2

  公开（公告）日：2012-07-31
• [EN] PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS<br/>[FR] DÉRIVÉS DE PYRIDAZINONE UTILES EN TANT QU'INHIBITEURS DE SYNTHASE DE GLUCANE
  申请人：SCHERING CORP

  公开号：WO2008115381A1

  公开（公告）日：2008-09-25

  [EN] In its many embodiments, the present invention provides -substituted pyridazinone compounds as glucan synthase inhibitors, methods of preparing such compounds, pharmaceutical including one or more of such compounds, methods of preparing pharmaceutical formulations including one or more such compounds or one or more such compounds along with other antifungal agents, and methods of treatment, prevention, inhibition, or amelioration of one or more fungal infections associated with glucan synthase using such compounds or pharmaceutical compositions.
  [FR] L'invention concerne des composés de pyridazinone substitués en tant qu'inhibiteurs de synthase de glucane ; des procédés de préparation de tels composés, des produits pharmaceutiques comprenant un ou plusieurs de ces composés ; des procédés de préparation de formulations pharmaceutiques comprenant un ou plusieurs de ces composés seuls ou avec d'autres agents antifongiques ; et des procédés de traitement, de prévention, d'inhibition, ou d'amélioration d'une ou de plusieurs infections fongiques associées à une synthase de glucane utilisant de tels composés ou compositions pharmaceutiques.