(2-Piperazin-1-yl-ethyl)-tetradecyl-amine | 94873-56-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (2-Piperazin-1-yl-ethyl)-tetradecyl-amine
• 英文别名: N-(2-piperazin-1-ylethyl)tetradecan-1-amine
• CAS: 94873-56-0
• 化学式: C₂₀H₄₃N₃
• 分子量: 325.582
• InChiKey: VNRLJVFSOZUJNJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  23
• 可旋转键数：
  16
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF AGENTS<br/>[FR] COMPOSÉS ET COMPOSITIONS POUR L'ADMINISTRATION INTRACELLULAIRE D'AGENTS
  申请人：MODERNATX INC

  公开号：WO2018232120A1

  公开（公告）日：2018-12-20

  The disclosure features amino lipids and compositions involving the same. Nanoparticle compositions include an amino lipid as well as additional lipids such as phospholipids, structural lipids, PEG lipids, or a combination thereof. Nanoparticle compositions further including therapeutic and/or prophylactic agents such as RNA are useful in the delivery of therapeutic and/or prophylactic agents to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

  该披露涉及氨基脂质和包含氨基脂质的组合物。纳米粒子组合物包括氨基脂质以及额外的脂质，如磷脂、结构脂质、PEG脂质或二者的组合。纳米粒子组合物还包括治疗和/或预防剂，如RNA，可用于将治疗和/或预防剂传递到哺乳动物细胞或器官，例如，调节多肽、蛋白质或基因表达。
• [EN] COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF AGENTS<br/>[FR] COMPOSÉS ET COMPOSITIONS POUR L'ADMINISTRATION INTRACELLULAIRE D'AGENTS THÉRAPEUTIQUES ET/OU PROPHYLACTIQUES
  申请人：MODERNATX INC

  公开号：WO2017112865A1

  公开（公告）日：2017-06-29

  The disclosure features amino lipids and compositions involving the same. Nanoparticle compositions include an amino lipid as well as additional lipids such as phospholipids, structural lipids, PEG lipids, or a combination thereof. Nanoparticle compositions further including therapeutic and/or prophylactic agents such as RNA are useful in the delivery of therapeutic and/or prophylactic agents to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

  该披露涉及氨基脂质和相关组合物。纳米粒子组合物包括氨基脂质以及额外的脂质，如磷脂、结构脂质、PEG脂质或二者的组合。纳米粒子组合物还包括治疗和/或预防剂，如RNA，可用于将治疗和/或预防剂传递至哺乳动物细胞或器官，例如，调节多肽、蛋白质或基因表达。
• Method of improving the compatibility of a fuel additive composition containing a mannich condensation product
  申请人：——

  公开号：US20040000089A1

  公开（公告）日：2004-01-01

  A method of improving the compatibility of a fuel additive composition comprising blending together the following components: a) a Mannich condensation product of (1) a high molecular weight alkyl-substituted hydroxyaromatic compound, (2) an amine having the formula: 1 wherein A is CH or nitrogen, R 1 , R 2 , R 3 are independently hydrogen or lower alkyl of 1 to about 6 carbon atoms and each R 2 and R 3 is independently selected in each —CR 2 R 3 — unit, and x is an integer from 1 to about 6; and (3) an aldehyde, wherein the respective molar ratio of reactants (1), (2), and (3) is 1:0.1-2:0.1-2; b) a hydrocarbyl-terminated poly(oxyalkylene) monool; c) a carboxylic acid as represented by the formula: R 4 (COOH) y wherein R 4 represents a hydrocarbyl group having about 2 to about 50 carbon atoms, and y represents an integer of 1 to about 4; and d) an anhydride selected from the group consisting of succinic, glutaric, phthalic, and alkyl anhydrides.

  一种改善燃料添加剂组合物的相容性的方法，包括混合以下组分：a）高分子量烷基取代的羟基芳香化合物的Mannich缩合物，其中该芳香化合物与1个具有以下公式的胺反应：1其中A是CH或氮，R1、R2、R3分别独立地表示氢或1到约6个碳原子的低级烷基，每个R2和R3在每个—CR2R3—单元中独立选择，x是1到约6的整数；以及1个醛，其中反应物（1）、（2）和（3）的各自摩尔比为1:0.1-2:0.1-2；b）烃基终止的聚（氧烷基）单醇；c）由以下公式表示的羧酸：R4（COOH）y其中R4表示具有约2到约50个碳原子的烃基，y表示1到约4的整数；以及d）从琥珀酸、戊二酸、邻苯二甲酸和烷基酸酐组成的羧酸酐。
• Fuel additive compositions containing a Mannich condensation product, a poly(oxyalkylene) monool, and a carboxylic acid
  申请人：Chevron Oronite Company LLC

  公开号：EP1323814A2

  公开（公告）日：2003-07-02

  A fuel additive composition comprising: a) a Mannich condensation product of (1) a high molecular weight alkyl-substituted hydroxyaromatic compound; (2) an amine having the formula: wherein A is CH or nitrogen, R1, R2, R3 are independently hydrogen or lower alkyl of 1 to about 6 carbon atoms and each R2 and R3 is independently selected in each -CR2R3- unit, and x is an integer from 1 to about 6; and (3) an aldehyde, wherein the respective molar ratio of reactants (1), (2), and (3) is 1:0.1-2:0.1-2; b) a hydrocarbyl-terminated poly(oxyalkylene) monool; and c) a carboxylic acid as represented by the formula:         R4(COOH)y or anhydride thereof, wherein R4 represents a hydrocarbyl group having about 2 to about 50 carbon atoms, and y represents an integer of 1 to about 4.

  一种燃料添加剂组合物，包括 a) (1) 高分子量烷基取代的羟基芳香化合物；(2) 具有以下式子的胺的曼尼希缩合产物： 其中 A 是 CH 或氮，R1、R2、R3 独立地是氢或 1 至约 6 个碳原子的低级烷基，每个 R2 和 R3 独立地选择在每个 -CR2R3- 单元中，且 x 是 1 至约 6 的整数； 和 (3) 醛，其中反应物(1)、(2)和(3)各自的摩尔比为 1:0.1-2:0.1-2； b) 烃基封端聚氧亚烷基单醇；以及 c) 如式所示的羧酸： R4(COOH)y 或其酸酐，其中 R4 代表具有约 2 至约 50 个碳原子的烃基，y 代表 1 至约 4 的整数。
• A method of improving the compatibility of a fuel additive composition containing a Mannich condensation product
  申请人：Chevron Oronite Company LLC

  公开号：EP1375629A2

  公开（公告）日：2004-01-02

  A method of improving the compatibility of a fuel additive composition comprising blending together the following components: a) a Mannich condensation product of (1) a high molecular weight alkyl-substituted hydroxyaromatic compound, (2) an amine having the formula: wherein A is CH or nitrogen, R1, R2, R3 are independently hydrogen or lower alkyl of 1 to about 6 carbon atoms and each R2 and R3 is independently selected in each -CR2R3- unit, and x is an integer from 1 to about 6; and (3) an aldehyde, wherein the respective molar ratio of reactants (1), (2), and (3) is 1:0.1-2:0.1-2; b) a hydrocarbyl-terminated poly(oxyalkylene) monool; c) a carboxylic acid as represented by the formula:         R4(COOH)y wherein R4 represents a hydrocarbyl group having about 2 to about 50 carbon atoms, and y represents an integer of 1 to about 4; and d) an anhydride selected from the group consisting of succinic, glutaric, phthalic, and alkyl anhydrides.

  一种改善燃料添加剂组合物相容性的方法，包括将以下成分混合在一起： a) (1) 高分子量烷基取代的羟基芳香化合物，(2) 式中的胺的曼尼希缩合产物： 其中 A 是 CH 或氮，R1、R2、R3 独立地是氢或 1 至约 6 个碳原子的低级烷基，每个 R2 和 R3 独立地选择在每个 -CR2R3- 单元中，x 是 1 至约 6 的整数； 和 (3) 醛，其中反应物(1)、(2)和(3)各自的摩尔比为 1:0.1-2:0.1-2； b) 烃基封端聚(氧亚烷基)一元醇 c) 如式所示的羧酸： R4(COOH)y 其中 R4 代表具有约 2 至约 50 个碳原子的烃基，y 代表 1 至约 4 的整数；以及 d) 选自琥珀酸酐、戊二酸酐、邻苯二甲酸酐和烷基酸酐的酸酐。