5-(1-Methyl-1H-indol-5-yl)-2-[4-(2,2,2-trifluoro-ethyl)-piperazin-1-yl]-benzooxazole | 1220281-99-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 5-(1-Methyl-1H-indol-5-yl)-2-[4-(2,2,2-trifluoro-ethyl)-piperazin-1-yl]-benzooxazole
• 英文别名: 5-(1-Methylindol-5-yl)-2-[4-(2,2,2-trifluoroethyl)piperazin-1-yl]-1,3-benzoxazole
• CAS: 1220281-99-1
• 化学式: C₂₂H₂₁F₃N₄O
• 分子量: 414.43
• InChiKey: PRLHULKJVJQFBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• [EN] COMPOUNDS USEFUL AS FAAH MODULATORS AND USES THEREOF<br/>[FR] COMPOSÉS UTILES EN TANT QUE MODULATEURS DE LA FAAH ET LEURS UTILISATIONS
  申请人：RENOVIS INC

  公开号：WO2010039186A2

  公开（公告）日：2010-04-08

  Compounds are disclosed that have formula I: wherein X, R1, R2, R3, R4 and n are as defined herein. The compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, anxiety, depression, inflammation, cognitive disorders, weight and eating disorders, Parkinson's disease, Alzheimer's disease, spasticity, addiction, glaucoma, and others.