1-[3-(3-methoxybenzyl)-[1,2,4]thiadiazol-5-yl]piperazine | 946419-01-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-[3-(3-methoxybenzyl)-[1,2,4]thiadiazol-5-yl]piperazine
• 英文别名: 1-[3-(3-Methoxy-benzyl)-[1,2,4]thiadiazol-5-yl]-piperazine；3-[(3-methoxyphenyl)methyl]-5-piperazin-1-yl-1,2,4-thiadiazole
• CAS: 946419-01-8
• 化学式: C₁₄H₁₈N₄OS
• 分子量: 290.389
• InChiKey: VITPKHYCLSPTJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  78.5
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES
  申请人：NV Remynd

  公开号：EP1981504A2

  公开（公告）日：2008-10-22
• THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURO-DEGENERATIVE DISEASES
  申请人：NV Remynd

  公开号：EP2094677A1

  公开（公告）日：2009-09-02
• THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
  申请人：GRIFFIOEN Gerard

  公开号：US20090054410A1

  公开（公告）日：2009-02-26

  This invention provides specifically substituted 1,2,4-thiadiazole derivatives for use in the treatment of an α-synucleopathy such as Parkinson's disease, diffuse Lewy body disease, traumatic brain injury, amyotrophic lateral sclerosis, Niemann-Pick disease, Hallervorden-Spatz syndrome, Down syndrome, neuroaxonal dystrophy, multiple system atrophy and Alzheimer's disease. This invention also provides various methods for producing such substituted 1,2,4-thiadiazole derivatives.
• US7960556B2
  申请人：——

  公开号：US7960556B2

  公开（公告）日：2011-06-14
• US8541406B2
  申请人：——

  公开号：US8541406B2

  公开（公告）日：2013-09-24