(-) Lithium 4β-(4'-Chlorophenyl)-1-methylpiperidine-3β-carboxylate | 357264-92-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (-) Lithium 4β-(4'-Chlorophenyl)-1-methylpiperidine-3β-carboxylate
• 英文别名: lithium;(3S,4S)-4-(4-chlorophenyl)-1-methylpiperidine-3-carboxylate
• CAS: 357264-92-7
• 化学式: C₁₃H₁₅ClNO₂*Li
• 分子量: 259.662
• InChiKey: YSGRYURMGKOREQ-MNMPKAIFSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.87
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Imaging agents for diagnosis of Parkinson's disease
  申请人：——

  公开号：US20010044543A1

  公开（公告）日：2001-11-22

  Generally, the present invention is directed to central nervous system dopamine transporter-imaging agents and methods of use thereof. In certain embodiments, the present invention relates to radiolabeled piperidine derivatives for use as imaging agents in the diagnosis of Parkinson's disease. Another aspect of the present invention relates to piperidine monoamine transporter ligands, comprising a functional group capable of chelating a radionuclide, e.g., technetium, and methods of use thereof.

  一般而言，本发明涉及中枢神经系统多巴胺转运体成像剂及其使用方法。在某些实施例中，本发明涉及用于帕金森病诊断中的放射性标记的哌啶衍生物成像剂。本发明的另一个方面涉及哌啶单胺转运体配体，包括一个能够螯合放射性核素（例如锝）的功能基团，以及其使用方法。
• Imaging agents for diagnosis of parkinson's disease
  申请人：——

  公开号：US20030208078A1

  公开（公告）日：2003-11-06

  Generally, the present invention is directed to central nervous system dopamine transporter-imaging agents and methods of use thereof. In certain embodiments, the present invention relates to radiolabeled piperidine derivatives for use as imaging agents in the diagnosis of Parkinson's disease. Another aspect of the present invention relates to piperidine monoamine transporter ligands, comprising a functional group capable of chelating a radionuclide, e.g., technetium, and methods of use thereof.
• IMAGING AGENTS FOR DIAGNOSIS OF PARKINSON'S DISEASE
  申请人：Babich John W.

  公开号：US20080312446A1

  公开（公告）日：2008-12-18

  Generally, the present invention is directed to central nervous system dopamine transporter-imaging agents and methods of use thereof. In certain embodiments, the present invention relates to radiolabeled piperidine derivatives for use as imaging agents in the diagnosis of Parkinson's disease. Another aspect of the present invention relates to piperidine monoamine transporter ligands, comprising a functional group capable of chelating a radionuclide, e.g., technetium, and methods of use thereof.
• US6515131B2
  申请人：——

  公开号：US6515131B2

  公开（公告）日：2003-02-04
• US6677454B2
  申请人：——

  公开号：US6677454B2

  公开（公告）日：2004-01-13