4-[(4-methyl-1H-indol-5-yl)amino]-5-[(E)-2-{4-[(4-pyridin-2-ylpiperazin-1-yl)methyl]phenyl}vinyl]nicotinonitrile | 1160919-16-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-[(4-methyl-1H-indol-5-yl)amino]-5-[(E)-2-{4-[(4-pyridin-2-ylpiperazin-1-yl)methyl]phenyl}vinyl]nicotinonitrile
• 英文别名: 4-[(4-methyl-1H-indol-5-yl)amino]-5-[(E)-2-[4-[(4-pyridin-2-ylpiperazin-1-yl)methyl]phenyl]ethenyl]pyridine-3-carbonitrile
• CAS: 1160919-16-3
• 化学式: C₃₃H₃₁N₇
• 分子量: 525.656
• InChiKey: QHYWKHISVYLMIN-MDZDMXLPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  40
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  83.9
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS
  申请人：Wyeth LLC

  公开号：EP2229377A1

  公开（公告）日：2010-09-22
• [EN] 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS<br/>[FR] 5-ALKYL/ALCÉNYL-3-CYANOPYRIDINES EN TANT QU'INHIBITEURS DE KINASE
  申请人：WYETH CORP

  公开号：WO2009076602A1

  公开（公告）日：2009-06-18

  Described herein are compounds of formula I: wherein G is and pharmaceutically acceptable salts thereof, wherein J, X, R1, R2, R11, R12' and p are as defined herein. Also provided herein are methods of making the compounds of formula I, and methods of using these compounds for inhibiting or treating a pathological condition or disorder linked to or mediated by a protein kinase in a mammal.