N-(1-(3-(methylthio)benzyl)piperidin-3-yl)-1H-indazol-5-amine | 1035095-17-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-(1-(3-(methylthio)benzyl)piperidin-3-yl)-1H-indazol-5-amine
• 英文别名: N-[1-[(3-methylsulfanylphenyl)methyl]piperidin-3-yl]-1H-indazol-5-amine
• CAS: 1035095-17-0
• 化学式: C₂₀H₂₄N₄S
• 分子量: 352.503
• InChiKey: NGHLZEZXRFLFJC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  69.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,2-Dimethyl-1-(5-(1-(3-(methylthio)benzoyl)piperidin-3-ylamino)-1H-indazol-1-yl)propan-1-one 在 dimethyl sulfide borane 作用下， 以 四氢呋喃 为溶剂， 以41%的产率得到N-(1-(3-(methylthio)benzyl)piperidin-3-yl)-1H-indazol-5-amine
  参考文献：
  名称：

  CYTOSKELETAL ACTIVE RHO KINASE INHIBITOR COMPOUNDS, COMPOSITION AND USE

  摘要：

  本发明涉及一种合成的细胞骨架活性化合物，其为rho相关蛋白激酶的抑制剂。本发明还涉及包含此类化合物和药用载体的制药组合物。此外，本发明还涉及一种预防或治疗与细胞骨架重组相关的疾病或病症的方法。在本发明的一个实施例中，该方法治疗增加的眼内压，如原发性开角型青光眼。该方法包括向受体施用公式I或公式II的细胞骨架活性化合物的治疗有效量，其中该量能够影响肌动蛋白相互作用，例如通过导致细胞松弛和细胞基质附着的改变。

  公开号：

  US20080214614A1

文献信息

• Cytoskeletal active rho kinase inhibitor compounds, composition and use
  申请人：Inspire Pharmaceuticals, Inc.

  公开号：US08071779B2

  公开（公告）日：2011-12-06

  The present invention is directed to synthetic cytoskeletal active compounds that are inhibitors of rho-associated protein kinase. The present invention is also directed to pharmaceutical compositions comprising such compounds and a pharmaceutically acceptable carrier. The invention is additionally directed to a method of preventing or treating diseases or conditions associated with cytoskeletal reorganization. In one embodiment of the invention, the method treats increased intraocular pressure, such as primary open-angle glaucoma. The method comprises administering to a subject a therapeutically effective amount of a cytoskeletal active compound of Formula I or Formula II, wherein said amount is effective to influence the actomyosin interactions, for example by leading to cellular relaxation and alterations in cell-substratum adhesions.

  本发明涉及合成的细胞骨架活性化合物，其为rho相关蛋白激酶的抑制剂。本发明还涉及包含这种化合物和药学上可接受的载体的制药组合物。此外，本发明还涉及一种预防或治疗与细胞骨架重组相关的疾病或症状的方法。在本发明的一种实施方式中，该方法治疗增加的眼内压，例如原发性开角型青光眼。该方法包括向受试者施用公式I或公式II的细胞骨架活性化合物的治疗有效量，其中该量有效地影响肌动蛋白相互作用，例如通过导致细胞松弛和细胞-基质粘附的改变。
• METHOD FOR TREATING PULMONARY DISEASES USING RHO KINASE INHIBITOR COMPOUNDS
  申请人：Inspire Pharmaceuticals, Inc.

  公开号：EP2400969A1

  公开（公告）日：2012-01-04
• METHOD FOR TREATING INFLAMMATORY DISEASES USING RHO KINASE INHIBITOR COMPOUNDS
  申请人：Fulcher Emilee H.

  公开号：US20090325960A1

  公开（公告）日：2009-12-31

  This invention is directed to methods of preventing or treating diseases or conditions associated with excessive cell proliferation, remodeling, edema and inflammation. Particularly, this invention is directed to methods of treating inflammatory diseases or conditions such as rheumatoid arthritis and inflammatory bowel disease. The method comprises identifying a subject in need of the treatment, and administering to the subject an effective amount of a compound of a novel rho kinase inhibitor compound to treat the disease.
• METHOD FOR TREATING DISEASES ASSOCIATED WITH ALTERATIONS IN CELLULAR INTEGRITY USING RHO KINASE INHIBITOR COMPOUNDS
  申请人：Peterson Ward M.

  公开号：US20090325905A1

  公开（公告）日：2009-12-31

  This invention is directed to methods of preventing or treating diseases or conditions associated with alterations in cellular integrity including alterations in endothelial permeability, excessive cell proliferation or tissue remodeling. Particularly, this invention is directed to methods of treating diabetic nephropathy, malaria, or cancer. The method comprises identifying a subject in need of the treatment, and administering to the subject an effective amount of a novel rho kinase inhibitor compound to treat the disease.
• METHOD FOR TREATING NEUROLOGICAL AND NEUROPATHIC DISEASES USING RHO KINASE INHIBITOR COMPOUNDS
  申请人：Navratil Tomas

  公开号：US20090325934A1

  公开（公告）日：2009-12-31

  This invention is directed to methods of preventing or treating neurological or neuropathic diseases or conditions associated with excessive inflammation, neurodegeneration, neuro-remodeling, and axonal/neurite retraction. Particularly, this invention relates to methods treating neurological or neuropathic diseases such as cerebral ischemia, stroke, neuropathic pain, spinal cord injury, Alzheimer's disease, and multiple sclerosis, using novel rho kinase inhibitor compounds. The method comprises identifying a subject in need of the treatment, and administering to the subject an effective amount of a novel rho kinase inhibitor compound to treat the disease.