5',5"-dibromopyrogallol-sulfonephthalein | 31236-09-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 5',5"-dibromopyrogallol-sulfonephthalein
• 英文别名: 4-Bromo-6-[3-(5-bromo-2,3,4-trihydroxyphenyl)-1,1-dioxo-2,1lambda6-benzoxathiol-3-yl]benzene-1,2,3-triol；4-bromo-6-[3-(5-bromo-2,3,4-trihydroxyphenyl)-1,1-dioxo-2,1λ6-benzoxathiol-3-yl]benzene-1,2,3-triol
• CAS: 31236-09-6
• 化学式: C₁₉H₁₂Br₂O₉S
• 分子量: 576.173
• InChiKey: YJCROBBLFUDXCG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  31
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  173
• 氢给体数：
  6
• 氢受体数：
  9

文献信息

• Dual resonance energy transfer nucleic acid probes
  申请人：——

  公开号：US20030129611A1

  公开（公告）日：2003-07-10

  Dual nucleic acid probes with resonance energy transfer moieties are provided. In particular, fluorescent or luminescent resonance energy transfer moieties are provided on hairpin stem-loop molecular beacon probes that hybridize sufficiently near each other on a subject nucleic acid, e.g. mRNA, to generate an observable interaction. The invention also provides lanthanide chelate luminescent resonance energy transfer moieties on linear and stem-loop probes that hybridize sufficiently near each other on a subject nucleic acid to generate an observable interaction. The invention thereby provides detectable signals for rapid, specific and sensitive hybridization determination in vivo. The probes are used in methods of detection of nucleic acid target hybridization for the identification and quantification of tissue and cell-specific gene expression levels, including response to external stimuli, such as drug candidates, and genetic variations associated with disease, such as cancer.

  提供带有谐振能量转移基团的双核酸探针。具体来说，在发明中，在发生足够接近的发夹式干环分子信标探针上提供了荧光或发光谐振能量转移基团，这些探针在主体核酸（如mRNA）上发生足够接近的杂交以产生可观察的相互作用。该发明还提供了在线性和发夹式探针上的镧系螯合物发光谐振能量转移基团，这些探针在主体核酸上发生足够接近的杂交以产生可观察的相互作用。因此，该发明提供了用于体内快速、特异和敏感的杂交测定的可检测信号。这些探针用于检测核酸靶标的杂交的方法，以确定和量化组织和细胞特异基因表达水平，包括对外部刺激（如药物候选物）的反应，以及与疾病（如癌症）相关的遗传变异。
• Activatable probes and methods for in vivo gene detection
  申请人：Bao Gang

  公开号：US20050287548A1

  公开（公告）日：2005-12-29

  Probes for detecting a target polynucleotide are provided. One aspect provides a molecular beacon probe set wherein the donor molecular beacon comprises a quantum dot and an acceptor molecular beacon comprises at least one reporter. The probes optionally comprise a protein transduction domain, targeting signal, or a combination thereof. Methods for detecting target polynucleotides using the disclosed probes are also provided.

  提供用于检测靶向多核苷酸的探针。一个方面提供了一种分子信标探针集合，其中供体分子信标包括量子点，受体分子信标包括至少一个报告基团。这些探针可以选择性地包括蛋白质转导域、靶向信号或二者的组合。还提供了使用所述探针检测靶向多核苷酸的方法。
• [EN] STEREODYNAMIC CHEMOSENSORS<br/>[FR] CHIMIOCAPTEURS STÉRÉODYNAMIQUES
  申请人：UNIV GEORGETOWN

  公开号：WO2014144197A1

  公开（公告）日：2014-09-18

  The present invention relates to multifunctional chemosensors that can measure the concentration, enantiomeric excess (ee), and absolute configuration of chiral compounds. The chemosensors described herein may contain a backbone moiety that is bonded to a fluorescent moiety and a moiety for bonding a chiral compound. Backbone moieties may include aromatic groups, for example, naphthyl. The chemosensors described herein are useful for measuring concentration, enantiomeric excess, and absolute configuration of organic molecules in areas such as high throughput screening.

  本发明涉及多功能化学传感器，可测量手性化合物的浓度、对映体过量（ee）和绝对构型。本文描述的化学传感器可能包含与荧光基团和用于结合手性化合物的基团结合的骨架基团。骨架基团可能包括芳香族基团，例如，萘基团。本文描述的化学传感器可用于在高通量筛选等领域测量有机分子的浓度、对映体过量和绝对构型。
• Oligonucleotides comprising a molecular switch
  申请人：Arnold J. Lyle

  公开号：US20050042638A1

  公开（公告）日：2005-02-24

  This invention relates to oligonucleotides comprising a molecular switch which may exist in an “open” or “closed” position. The molecular switch portion of the probe is particularly sensitive to the identity of sequences complementary to the molecular switch. Oligonucleotides containing a molecular switch are applicable to all kinds of hybridization processes. Due to the sensitivity of the switch domain of the oligonucleotide, probes containing a molecular switch are particularly useful in the identification of single point mismatches. More specifically, a portion, but not all, of the oligonucleotide becomes unbound from a mismatched target. The invention further relates to methods of using said oligonucleotides for research reagents, and clinical diagnostics. An exemplary oligonucleotide comprises a first hybridizable domain, a second bridging block domain, and a third binding domain.

  这项发明涉及含有分子开关的寡核苷酸，该分子开关可以处于“打开”或“关闭”位置。探针的分子开关部分对与其互补的序列的身份特别敏感。含有分子开关的寡核苷酸适用于各种杂交过程。由于寡核苷酸的开关域的敏感性，含有分子开关的探针在单点错配的识别中特别有用。更具体地说，寡核苷酸的部分而不是全部会与错配目标解离。该发明还涉及使用上述寡核苷酸作为研究试剂和临床诊断的方法。一个示例性的寡核苷酸包括第一可杂交结构域、第二桥接块结构域和第三结合结构域。
• [EN] NOVEL COMPOSITIONS FOR LABELING BIOMOLECULES AND METHODS USING SAME<br/>[FR] NOUVELLES COMPOSITIONS DE MARQUAGE DE BIOMOLÉCULES ET PROCÉDÉS LES UTILISANT
  申请人：UNIV CALIFORNIA

  公开号：WO2017196544A1

  公开（公告）日：2017-11-16

  The present invention includes novel compounds useful for labeling biomolecules. The present invention further includes a novel method of labeling a biomolecule using a compound of the invention. The present invention further includes a novel method of imaging a biomolecule using a compound of the invention.

  本发明包括用于标记生物分子的新化合物。本发明还包括使用该发明的化合物标记生物分子的新方法。本发明还包括使用该发明的化合物成像生物分子的新方法。