isobutyric acid-(dimethyl-phenyl-silanyl ester) | 18053-84-4

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: isobutyric acid-(dimethyl-phenyl-silanyl ester)
• 英文别名: Isobutyryloxy-dimethyl-phenyl-silan；Isobuttersaeure-(dimethyl-phenyl-silylester)；[dimethyl(phenyl)silyl] 2-methylpropanoate
• CAS: 18053-84-4
• 化学式: C₁₂H₁₈O₂Si
• 分子量: 222.359
• InChiKey: MYGLXXNZSYJUDZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  二甲基苯基硅烷 、 异丁酸 在 [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ 作用下， 反应 3.0h， 以74%的产率得到isobutyric acid-(dimethyl-phenyl-silanyl ester)
  参考文献：
  名称：

  甲硅烷基酯和甲硅烷基醚的高效无溶剂路线

  摘要：

  Abstractmagnified imageDinuclear metal complexes, especially (p‐cymene)ruthenium dichloride dimer {[RuCl2(p‐cymene)]2}, have been found to exhibit high catalytic performance for the dehydrosilylation of various kinds of carboxylic acids and alcohols. The dehydrosilylation with [RuCl2(p‐cymene)]2 proceeded efficiently with only one equivalent of silane with respect to substrate (carboxylic acids or alcohols) under solvent‐free conditions to give the corresponding silyl esters and ethers in excellent yields with a high turnover number (TON) and frequency (TOF). The 1H NMR spectrum of a toluene‐d8 solution of [RuCl2(p‐cymene)]2 and a silane showed a signal assignable to the ruthenium hydride species. In contrast, no new signals were detected in the 1H NMR spectrum of a toluene‐d8 solution of [RuCl2(p‐cymene)]2 and a carboxylic acid or an alcohol. Therefore, the ruthenium metal in [RuCl2(p‐cymene)]2 activates a silane to afford the hydride intermediate, possibly a silylmetal hydride species. Then, the nucleophilic attack of a substrate (carboxylic acid or alcohol) to the hydride intermediate proceeds to give the corresponding silylated product. The present dehydrosilylation with an optically active silane proceeded exclusively under inversion of stereochemistry at the chiral silicon center, suggesting that the nucleophilic attack of a substrate to the hydride intermediate occurs from the backside of the ruthenium‐silicon bond.

  DOI：

  10.1002/adsc.200900230

文献信息

• Ectopic salivary gland tissue in the anterior mandible: a case report
  作者：M Dorman、D Pierse

  DOI：10.1038/sj.bdj.4801629

  日期：2002.11

  Ectopic salivary gland inclusions in the mandible are a rare phenomenon. Classically as described by Stafne1 they have been found in the posterior mandibular region. Cases affecting the anterior mandible are even more unusual. We report a case of ectopic salivary gland tissue in the anterior mandible. In our discussion we emphasise the need for a thorough history, examination and relevant investigations. Mandibular radiolucencies can prove a pitfall for the unwary.

  下颌异位涎腺内含物是一种罕见现象。根据 Stafne1 的描述，异位涎腺通常出现在下颌后部。影响下颌前部的病例更为罕见。我们报告了一例下颌骨前部的异位唾液腺组织。在讨论中，我们强调了详细询问病史、检查和相关检查的必要性。下颌骨放射性肿物可能会给不小心的人带来麻烦。