2-(2-difluoromethylbenzimidazol-1-yl)-4-(4-methoxylacetylpiperazin-1-yl)-6-morpholino-1,3,5-triazine | 909300-17-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-(2-difluoromethylbenzimidazol-1-yl)-4-(4-methoxylacetylpiperazin-1-yl)-6-morpholino-1,3,5-triazine
• 英文别名: 2-(2-difluoromethylbenzimidazol-1-yl)-4-(4-methoxyacetylpiperazin-1-yl)-6-morpholino-1,3,5-triazine；1-[4-[4-[2-(Difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]piperazin-1-yl]-2-methoxyethanone
• CAS: 909300-17-0
• 化学式: C₂₂H₂₆F₂N₈O₃
• 分子量: 488.497
• InChiKey: LCWNJRUKTAQWHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  102
• 氢给体数：
  0
• 氢受体数：
  11

文献信息

• IMMUNOSUPPRESSIVE AGENT AND ANTI-TUMOR AGENT COMPRISING HETEROCYCLIC COMPOUND AS ACTIVE INGREDIENT
  申请人：Haruta Kazuhiko

  公开号：US20080113987A1

  公开（公告）日：2008-05-15

  A novel method for immunosuppressive in a mammal suffering from an immune disease, including administering to the mammal a therapeutically effective amount of a heterocyclic compound represented by the general formula (I) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is disclosed. A novel heterocyclic compound represented by the general formula (II) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is also disclosed.

  本发明涉及一种治疗免疫性疾病的哺乳动物的免疫抑制新方法，包括向哺乳动物施用一种由通式（I）表示的杂环化合物的治疗有效量或其药学上可接受的盐。其中X或其他变量的定义见说明书。本发明还涉及一种由通式（II）表示的新型杂环化合物或其药学上可接受的盐。
• IMMUNOSUPPRESSIVE AGENT COMPRISING A HETEROCYCLIC COMPOUND AS ACTIVE INGREDIENT
  申请人：ZENYAKU KOGYO KABUSHIKIKAISHA

  公开号：EP1864665B1

  公开（公告）日：2012-05-16
• US7750001B2
  申请人：——

  公开号：US7750001B2

  公开（公告）日：2010-07-06
• US8338414B2
  申请人：——

  公开号：US8338414B2

  公开（公告）日：2012-12-25