2-Methyl-2-(piperazin-1-yl)propan-1-ol dihydrochloride | 873066-14-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-Methyl-2-(piperazin-1-yl)propan-1-ol dihydrochloride
• 英文别名: 2-methyl-2-piperazin-1-ylpropan-1-ol;dihydrochloride
• CAS: 873066-14-9
• 化学式: C8H20Cl2N2O
• mdl: MFCD18917291
• 分子量: 231.16
• InChiKey: APPDNESLCCLETD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.34
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.5
• 氢给体数：
  4
• 氢受体数：
  3

文献信息

• NOVEL THIENOPYRROLE COMPOUNDS
  申请人：Wishart Neil

  公开号：US20110152243A1

  公开（公告）日：2011-06-23

  The invention provides a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

  该发明提供了公式（I）的化合物，包括药用盐、前药、生物活性代谢物、立体异构体和同分异构体，其中变量在此处定义。该发明的化合物可用于治疗免疫和肿瘤疾病。
• Substituted N-arylsulfonylheterocyclic amines as gamma-secretase inhibitors
  申请人：Josien B. Hubert

  公开号：US20060040936A1

  公开（公告）日：2006-02-23

  This invention discloses novel gamma secretase inhibitors of the formula: wherein: L is —O—, —N(R 6 )—, —S—, —S(O)—, or —S(O 2 )—; R 1 is selected from the group consisting of aryl and heteroaryl; R 2 is selected from the group consisting of alkyl, —C(O)—Y, —X—C(O)—Y, -alkylene-X—C(O)—Y, -alkylene-C(O)—Y, -alkylene-cycloalkylene-X—C(O)—Y, -alkylene-cycloalkylene-C(O)—Y, -cycloalkylene-alkylene-X—C(O)—Y, -cycloalkylene-alkylene-C(O)—Y, -cycloalkylene-X—C(O)—Y, -cycloalkylene-C(O)—Y, -alkylene-cycloalkylene-alkylene-X—C(O)—Y, -alkylene-cycloalkylene-alkylene-C(O)—Y, aryl, and heteroaryl; R 3 is selected from the group consisting of aryl, heteroaryl, alkyl, cycloalkyl, arylalkyl, arylcycloalkyl, heteroarylalkyl, heteroarylcycloalkyl, arylheterocycloalkyl, and alkoxyalkyl; each R 4 and R 5 is independently selected from the group consisting of H and alkyl; and Y is selected from the group consisting of —NR 8 R 9 , —N(R 6 )—(CH 2 ) b —NR 8 R 9 , aryl, heteroaryl, alkyl, cycloalkyl, arylalkyl, arylcycloalkyl, heteroarylalkyl, heteroarylcycloalkyl, and arylheterocycloalkyl; or Y is selected from the group consisting of: One or more compounds of formula I, or formulations comprising such compounds, may be useful, e.g. in treating Alzheimer's Disease.

  本发明公开了式如下的新型γ 分泌酶抑制剂： 其中 L是-O-、-N(R 6 )-、-S-、-S(O)-或-S(O 2 )-; R 1 选自由芳基和杂芳基组成的组； R 2 选自由烷基、-C(O)-Y、-X-C(O)-Y、-亚烷基-X-C(O)-Y、-亚烷基-C(O)-Y、-亚烷基-环亚烷基-X-C(O)-Y、-亚烷基-环亚烷基-C(O)-Y、-环亚烷基-亚烷基-X-C(O)-Y-环亚烷基-亚烷基-C(O)-Y、-环亚烷基-亚烷基-X-C(O)-Y、-环亚烷基-亚烷基-X-C(O)-Y、-亚烷基-环亚烷基-亚烷基-C(O)-Y、芳基和杂芳基； R 3 选自由芳基、杂芳基、烷基、环烷基、芳基烷基、芳基环烷基、杂芳基烷基、杂芳基环烷基、芳基杂环烷基和烷氧基烷基组成的组； 每个 R 4 和 R 5 独立选自由 H 和烷基组成的组；以及 Y 选自 -NR 8 R 9 、-N（R 6 )-(CH 2 ) b -NR 8 R 9 、芳基、杂芳基、烷基、环烷基、芳基烷基、芳基环烷基、杂芳基烷基、杂芳基环烷基和芳基杂环烷基；或 Y 选自以下组成的组 一种或多种式 I 化合物或包含此类化合物的制剂可用于治疗阿尔茨海默病等。
• SUBSTITUTED N-ARYLSULFONYLHETEROCYCLIC AMINES AS GAMMA-SECRETASE INHIBITORS
  申请人：Schering Corporation

  公开号：EP1789404B1

  公开（公告）日：2010-03-24
• Substituted N-Arylsulfonylheterocyclic Amines As Gamma-Secretase Inhibitors
  申请人：Josien Hubert B.

  公开号：US20100087425A1

  公开（公告）日：2010-04-08

  This invention discloses novel gamma secretase inhibitors of the formula: wherein: L is —O—, —N(R 6 )—, —S—, —S(O)—, or —S(O 2 )—; R 1 is selected from the group consisting of aryl and heteroaryl; R 2 is selected from the group consisting of alkyl, —C(O)—Y, —X—C(O)—Y, -alkylene-X—C(O)—Y, -alkylene-C(O)—Y, -alkylene-cycloalkylene-X—C(O)—Y, -alkylene-cycloalkylene-C(O)—Y, -cycloalkylene-alkylene-X—C(O)—Y, -cycloalkylene-alkylene-C(O)—Y, -cycloalkylene-X—C(O)—Y, -cycloalkylene-C(O)—Y, -alkylene-cycloalkylene-alkylene-X—C(O)—Y, -alkylene-cycloalkylene-alkylene-C(O)—Y, aryl, and heteroaryl; R 3 is selected from the group consisting of aryl, heteroaryl, alkyl, cycloalkyl, arylalkyl, arylcycloalkyl, heteroarylalkyl, heteroarylcycloalkyl, arylheterocycloalkyl, and alkoxyalkyl; each R 4 and R 5 is independently selected from the group consisting of H and alkyl; and Y is selected from the group consisting of —NR 8 R 9 , —N(R 6 )—(CH 2 ) b —NR 8 R 9 , aryl, heteroaryl, alkyl, cycloalkyl, arylalkyl, arylcycloalkyl, heteroarylalkyl, heteroarylcycloalkyl, and aryl heterocycloalkyl; or Y is selected from the group consisting of: One or more compounds of formula I, or formulations comprising such compounds, may be useful, e.g. in treating Alzheimer's Disease.
• US7763613B2
  申请人：——

  公开号：US7763613B2

  公开（公告）日：2010-07-27