4,4'-双（马来酰氨基）偶氮苯 | 77280-58-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 偶氮苯
• 中文名称: 4,4'-双（马来酰氨基）偶氮苯
• 英文名称: 4,4'-bis(maleimido)azobenzene
• 英文别名: 4,4'-Bis(maleoylamino)azobenzene；1-[4-[[4-(2,5-dioxopyrrol-1-yl)phenyl]diazenyl]phenyl]pyrrole-2,5-dione
• CAS: 77280-58-1
• 化学式: C₂₀H₁₂N₄O₄
• 分子量: 372.34
• InChiKey: IEMFDYPKHKLPGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  99.5
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4,4'-双（马来酰氨基）偶氮苯 以 二甲基亚砜 为溶剂， 生成 (E)-1,1'-(diazene-1,2-diylbis(4,1-phenylene))bis(1H-pyrrole-2,5-dione)
  参考文献：
  名称：

  New azobenzene derivatives for directed modification of proteins

  摘要：

  Derivatives of azobenzene which contained a maleimide group in one of the benzene rings (for binding to a protein cysteine residue) and maleimide, hydroxyl, or carboxyl substitutes in another benzene ring were synthesized. The reactivity of these compounds towards a cysteine residue of a protein and their optical properties in a free form and after their attachment to the mutant forms of the SsoII restriction endonuclease were studied.

  DOI：

  10.1134/s1068162009050033
• 作为产物：
  描述：

  在 sodium acetate 、 乙酸酐 作用下， 反应 0.75h， 以1.69 g的产率得到4,4'-双（马来酰氨基）偶氮苯
  参考文献：
  名称：

  New azobenzene derivatives for directed modification of proteins

  摘要：

  Derivatives of azobenzene which contained a maleimide group in one of the benzene rings (for binding to a protein cysteine residue) and maleimide, hydroxyl, or carboxyl substitutes in another benzene ring were synthesized. The reactivity of these compounds towards a cysteine residue of a protein and their optical properties in a free form and after their attachment to the mutant forms of the SsoII restriction endonuclease were studied.

  DOI：

  10.1134/s1068162009050033

文献信息

• US4211860A
  申请人：——

  公开号：US4211860A

  公开（公告）日：1980-07-08
• US4211861A
  申请人：——

  公开号：US4211861A

  公开（公告）日：1980-07-08
• New azobenzene derivatives for directed modification of proteins
  作者：Le Thi Hien、B. Schierling、A. Yu. Ryazanova、T. S. Zatsepin、E. M. Volkov、E. A. Kubareva、T. I. Velichko、A. Pingoud、T. S. Oretskaya

  DOI：10.1134/s1068162009050033

  日期：2009.9

  Derivatives of azobenzene which contained a maleimide group in one of the benzene rings (for binding to a protein cysteine residue) and maleimide, hydroxyl, or carboxyl substitutes in another benzene ring were synthesized. The reactivity of these compounds towards a cysteine residue of a protein and their optical properties in a free form and after their attachment to the mutant forms of the SsoII restriction endonuclease were studied.