2-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]-4-{4-[4-(3-trifluoromethylphenyl)-1-piperazinyl]phenyl}-3-(2H,4H)-1,2,4-triazolone | 359825-16-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]-4-{4-[4-(3-trifluoromethylphenyl)-1-piperazinyl]phenyl}-3-(2H,4H)-1,2,4-triazolone
• 英文别名: 2-[2-(2,4-Difluorophenyl)-2-hydroxy-3-(1,2,4-triazol-1-yl)propyl]-4-[4-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one
• CAS: 359825-16-4
• 化学式: C₃₀H₂₇F₅N₈O₂
• 分子量: 626.589
• InChiKey: BPEBWCJAGJQLQB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  45
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  93.3
• 氢给体数：
  1
• 氢受体数：
  12

文献信息

• AZOLE COMPOUNDS AS THERAPEUTIC AGENTS FOR FUNGAL INFECTIONS
  申请人：Ranbaxy Laboratories, Limited

  公开号：EP1278755A2

  公开（公告）日：2003-01-29
• US6670363B1
  申请人：——

  公开号：US6670363B1

  公开（公告）日：2003-12-30
• [EN] AZOLE COMPOUNDS AS THERAPEUTIC AGENTS FOR FUNGAL INFECTIONS<br/>[FR] COMPOSES AZOLE COMME AGENTS THERAPEUTIQUES POUR TRAITER DES INFECTIONS MYCOSIQUES
  申请人：RANBAXY LAB LTD

  公开号：WO2001066551A2

  公开（公告）日：2001-09-13

  The present invention relates to the derivatives of specially substituted azole compounds which have improved antifungal activity as compared to known compounds such as fluconazole and itraconazole and the processes for the preparation thereof. This invention also relates to pharmaceutical compositions containing the compounds of the present invention and their use in treating and/or preventing fungal infections in mammals, preferably humans.