5-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-6'-[4-(2-dimethylaminoethyl)piperazin-1-yl]-[3,3']bipyridinyl-6-ylamine | 877620-46-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 5-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-6'-[4-(2-dimethylaminoethyl)piperazin-1-yl]-[3,3']bipyridinyl-6-ylamine
• 英文别名: 3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[6-[4-[2-(dimethylamino)ethyl]piperazin-1-yl]pyridin-3-yl]pyridin-2-amine
• CAS: 877620-46-7
• 化学式: C₂₆H₃₁Cl₂FN₆O
• 分子量: 533.476
• InChiKey: YQDAFBAMJUUROR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  70.8
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• [EN] AMINOHETEROARYL COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS<br/>[FR] COMPOSES AMINOHETEROARYLES EN TANT QU'INHIBITEURS DES PROTEINES TYROSINE KINASES
  申请人：PFIZER

  公开号：WO2006021886A1

  公开（公告）日：2006-03-02

  Aminoheteroaryl compounds are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.

  提供了氨基杂环芳基化合物，以及它们的合成和使用方法。优选化合物是c-Met蛋白激酶的强效抑制剂，并且在治疗异常细胞生长紊乱，如癌症方面具有用处。
• Aminoheteroaryl compounds as protein kinase inhibitors
  申请人：Cui Jean Jingrong

  公开号：US20060178374A1

  公开（公告）日：2006-08-10

  Aminoheteroaryl compounds are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.

  提供了氨基杂环芳基化合物，以及它们的合成和使用方法。优选化合物是c-Met蛋白激酶的强力抑制剂，并且在治疗异常细胞生长障碍，如癌症方面非常有用。
• AMINOHETEROARYL COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS
  申请人：Pfizer, Inc.

  公开号：EP1786777A1

  公开（公告）日：2007-05-23