(1Z)-N'-hydroxy-2-(1-methylpiperidin-4-yl)ethanimidamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (1Z)-N'-hydroxy-2-(1-methylpiperidin-4-yl)ethanimidamide
• 英文别名: (Z)-N'-Hydroxy-2-(1-methylpiperidin-4-yl)acetimidamide；N'-hydroxy-2-(1-methylpiperidin-4-yl)ethanimidamide
• 化学式: C₈H₁₇N₃O
• mdl: MFCD15146528
• 分子量: 171.242
• InChiKey: OZOVEEGYIBBXPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  61.8
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (1Z)-N'-hydroxy-2-(1-methylpiperidin-4-yl)ethanimidamide 、 7-[1-(tert-butoxycarbonyl)piperidin-4-yl]-5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid 在 N,N-二异丙基乙胺 、 N,N'-羰基二咪唑 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.5h， 生成 tert-butyl 4-(3-{3-[(1-methylpiperidin-4-yl)methyl]-1,2,4-oxadiazol-5-yl}-5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate
  参考文献：
  名称：

  [EN] PIPERIDINYLPYRAZOLOPYRIMIDINONES AND THEIR USE
  [FR] PIPÉRIDINYLPYRAZOLOPYRIMIDINONES ET LEUR UTILISATION

  摘要：

  本申请涉及新型取代哌啶基吡唑吡嘧啶酮，以及它们的制备方法，这些化合物可单独或组合使用于治疗和/或预防疾病的方法中，特别是用于治疗和/或预防患有或不患有基础遗传或获得性止血障碍的患者的急性和复发性出血，其中出血与从重经期出血、产后出血、出血性休克、出血性膀胱炎、胃肠道出血、创伤、手术、移植、中风、肝脏疾病、遗传性血管性水肿、鼻血、以及血液积聚后的滑膜炎和软骨损伤等一组疾病或医疗干预有关。

  公开号：

  WO2016071216A1

文献信息

• [EN] OXADIAZOLE COMPOUNDS, THEIR PREPARATION AND USE<br/>[FR] COMPOSÉS OXADIAZOLE, LEUR PRÉPARATION ET LEUR UTILISATION
  申请人：PIRAMAL LIFE SCIENCES LTD

  公开号：WO2011104680A1

  公开（公告）日：2011-09-01

  The present invention relates to oxadiazole compounds in all their stereoisomeric and tautomeric forms and mixtures thereof in all ratios; and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, pharmaceutically acceptable prodrugs and pharmaceutically acceptable polymorphs. The invention also relates to processes for the manufacture of the oxadiazole compounds and to pharmaceutical compositions containing them. The said compounds and their pharmaceutical compositions are useful in the treatment of cancer, particularly chronic myeloid leukemia (CML). The present invention further provides a method of treatment of cancer by administering a therapeutically effective amount of said compounds or their pharmaceutical compositions, to a mammal in need thereof.

  本发明涉及氧代唑化合物的所有立体异构体和互变异构体形式以及它们在所有比例的混合物中；以及它们的药学上可接受的盐、药学上可接受的溶剂化合物、药学上可接受的前药和药学上可接受的多形态。该发明还涉及制备氧代唑化合物的方法以及含有它们的药物组合物。所述化合物及其药物组合物可用于治疗癌症，特别是慢性髓样白血病（CML）。本发明还提供了一种治疗癌症的方法，即通过向需要的哺乳动物投予所述化合物或其药物组合物的治疗有效剂量。
• OXADIAZOLE COMPOUNDS, THEIR PREPARATION AND USE
  申请人：Sivakumar Meenakshi

  公开号：US20130005771A1

  公开（公告）日：2013-01-03

  The present invention relates to oxadiazole compounds in all their stereoisomeric and tautomeric forms and mixtures thereof in all ratios; and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, pharmaceutically acceptable prodrugs and pharmaceutically acceptable polymorphs. The invention also relates to processes for the manufacture of the oxadiazole compounds and to pharmaceutical compositions containing them. The said compounds and their pharmaceutical compositions are useful in the treatment of cancer, particularly chronic myeloid leukemia (CML). The present invention further provides a method of treatment of cancer by administering a therapeutically effective amount of said compounds or their pharmaceutical compositions, to a mammal in need thereof.

  本发明涉及噁唑烷化合物及其所有立体异构体、互变异构体和所有比例的混合物，以及它们的药学上可接受的盐、药学上可接受的溶剂化合物、药学上可接受的前药和药学上可接受的多型体。本发明还涉及制造噁唑烷化合物的方法以及包含它们的制药组合物。所述化合物及其制药组合物在治疗癌症，特别是慢性髓细胞白血病（CML）方面有用。本发明还提供了一种通过向需要治疗的哺乳动物中投与所述化合物或其制药组合物的治疗有效量来治疗癌症的方法。
• Piperidinylpyrazolopyrimidinones and their use
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US10118930B2

  公开（公告）日：2018-11-06

  The present application relates to novel substituted piperidinylpyrazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired hemostatic disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of heavy menstrual bleeding, postpartum hemorrhage, hemorrhagic shock, hemorrhagic cystitis, gastrointestinal hemorrhage, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.

  本申请涉及新型取代的哌啶基吡唑嘧啶酮、其制备工艺、化合物在治疗和/或预防疾病的方法中的单独使用或组合使用，特别是用于治疗和/或预防有或没有潜在遗传性或获得性止血障碍的患者的急性和复发性出血、其中，出血与疾病或医疗干预有关，这些疾病或医疗干预选自月经大量出血、产后出血、失血性休克、出血性膀胱炎、胃肠道出血、创伤、手术、移植、中风、肝脏疾病、遗传性血管性水肿、鼻出血以及血汗管病后的滑膜炎和软骨损伤组成的组。
• PIPERIDINYLPYRAZOLOPYRIMIDINONES AND THEIR USE
  申请人：Bayer Pharma Aktiengesellschaft

  公开号：EP3215505B1

  公开（公告）日：2019-07-24
• US8629277B2
  申请人：——

  公开号：US8629277B2

  公开（公告）日：2014-01-14