9-azabicyclo[3.3.1]nonane-N-oxoammonium cation | 73324-62-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 9-azabicyclo[3.3.1]nonane-N-oxoammonium cation
• 英文别名: 9-oxo-9-azoniabicyclo[3.3.1]nonane；ABNO+；9-Azoniabicyclo[3.3.1]nonane 9-oxide
• CAS: 73324-62-6
• 化学式: C₈H₁₄NO
• 分子量: 140.205
• InChiKey: FHOVIUFUZJEXDN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• OXIDATION REACTION EXCELLENT IN CONVERSION RATE
  申请人：PAION UK LIMITED

  公开号：US20160009680A1

  公开（公告）日：2016-01-14

  A process for preparing 3-[(S)-7-bromo-2-(2-oxo-propylamino)-5-pyridin-2-yl-3H-1,4,-benzodiazepin-3-yl]propionic acid methyl ester at a high conversion rate with good reproducibility by oxidizing 3-[(S)-7-bromo-2-(2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester in the presence of an oxidation catalyst is provided by defining the ammonium ion content of 3-[(S)-7-bromo-2-(2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester.

  提供一种通过在氧化催化剂存在下氧化3-[(S)-7-溴-2-(2-羟基丙基氨基)-5-吡啶-2-基-3H-苯并二氮杂环-3-基]丙酸甲酯，以高转化率和良好的可重复性制备3-[(S)-7-溴-2-(2-氧代丙基氨基)-5-吡啶-2-基-3H-1,4-苯并二氮杂环-3-基]丙酸甲酯的方法，通过确定3-[(S)-7-溴-2-(2-羟基丙基氨基)-5-吡啶-2-基-3H-苯并二氮杂环-3-基]丙酸甲酯中铵离子含量实现。
• OXIDATION REACTION WITH EXCELLENT CONVERSION RATE
  申请人：Paion UK Limited

  公开号：EP2966069A1

  公开（公告）日：2016-01-13

  A process for preparing 3-[(S)-7-bromo-2-(2-oxo-propylamino)-5-pyridin-2-yl-3H-1,4,-benzodiazepin-3-yl]propionic acid methyl ester at a high conversion rate with good reproducibility by oxidizing 3-[(S)-7-bromo-2-(2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester in the presence of an oxidation catalyst is provided by defining the ammonium ion content of 3-[(S)-7-bromo-2-(2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester.

  一种制备 3-[(S)-7-溴-2-(2-氧代-丙基氨基)-5-吡啶-2-基-3H-1,4,-苯并二氮杂卓-3-基]丙酸甲酯的工艺，在氧化催化剂存在下，通过确定 3-[(S)-7-溴-2-(2-羟基-丙基氨基)-5-吡啶-2-基-3H-苯并[e][1、(S)-7-溴-2-(2-羟基-丙基氨基)-5-吡啶-2-基-3H-苯并[e][1,4]二氮杂卓-3-基]丙酸甲酯的铵离子含量。
• Process for preparing 3-[(S)-7-bromo-2-((2-oxopropyl)amino)-5-pyridin-2-yl-3H-1,4-benzodiazepin-3-yl]propionic acid methyl ester
  申请人：PAION UK LIMITED

  公开号：US10414749B2

  公开（公告）日：2019-09-17

  A process for preparing 3-[(S)-7-bromo-2-((2-oxo propyl)amino)-5-pyridin-2-yl-3H-1,4,-benzodiazepin-3-yl]propionic acid methyl ester (compound (FK)), at a high conversion rate with good reproducibility by oxidizing 3-[(S)-7-bromo-2-(2-hydroxypropylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3yl]propionic acid methyl ester (compound (EM)), in the presence of an oxidation catalyst is provided by defining the ammonium ion content of the oxidation reaction mixture.

  一种制备 3-[(S)-7-溴-2-((2-氧代丙基)氨基)-5-吡啶-2-基-3H-1,4,-苯并二氮杂卓-3-基]丙酸甲酯（化合物 (FK)）的工艺，通过氧化 3-[(S)-7-溴-2-(2-羟基丙基氨基)-5-吡啶-2-基-3H-苯并[e][1、4]二氮杂卓-3-基]丙酸甲酯（化合物 (EM)）的氧化反应。
• PROCESS FOR PREPARING 3-[(S)-7-BROMO-2-(2-OXOPROPYLAMINO)-5-PYRIDIN-2-YL-3H-1,4-BENZODIAZEPIN-3-YL]PROPIONIC ACID METHYL ESTER
  申请人：PAION UK LIMITED

  公开号：US20170217925A1

  公开（公告）日：2017-08-03

  A process for preparing 3-[(S)-7-bromo-2-(2-oxo-propylamino)-5-pyridin-2-yl-3H-1,4,-benzodiazepin-3-yl]propionic acid methyl ester at a high conversion rate with good reproducibility by oxidizing 3-[(S)-7-bromo-2-(2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester in the presence of an oxidation catalyst is provided by defining the ammonium ion content of 3-[(S)-7-bromo-2-(2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester.
• PROCESS FOR PREPARING 3-[(4S)-8-BROMO-1-METHYL-6-(2-PYRIDINYL)-4H-IMIDAZO[1,2-a][1,4]BENZODIAZEPIN-4-YL]PROPIONIC ACID METHYL ESTER BENZENESULFONATE
  申请人：PAION UK LIMITED

  公开号：US20180141928A1

  公开（公告）日：2018-05-24

  A process for preparing 3-[(S)-7-bromo-2-(2-oxo-propylamino)-5-pyridin-2-yl-3H-1,4,-benzodiazepin-3-yl]propionic acid methyl ester at a high conversion rate with good reproducibility by oxidizing 3-[(S)-7-bromo-2-(2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester in the presence of an oxidation catalyst is provided by defining the ammonium ion content of 3-[(S)-7-bromo-2-(2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester.