3,4-difluoro-2-(4-iodo-2-methyl-phenylamino)-5-[1-(4-pyridin-2-yl-piperazin-1-yl)-methanoyl]-benzoic acid | 1102238-01-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 3,4-difluoro-2-(4-iodo-2-methyl-phenylamino)-5-[1-(4-pyridin-2-yl-piperazin-1-yl)-methanoyl]-benzoic acid
• 英文别名: 3,4-Difluoro-2-(4-iodo-2-methylanilino)-5-(4-pyridin-2-ylpiperazine-1-carbonyl)benzoic acid
• CAS: 1102238-01-6
• 化学式: C₂₄H₂₁F₂IN₄O₃
• 分子量: 578.357
• InChiKey: DTYBLXWJIAFDHS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  85.8
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• 5-Amide substituted diarylamines as mex inhibitors
  申请人：——

  公开号：US20030225076A1

  公开（公告）日：2003-12-04

  Diarylanines, such as 5-amide substituted diarylamines of formula (I) or formula (II) wherein A is hydroxy, C 1-6 alkoxy, or NR 6 OR 7 ; X is OR 12 , NR 13 R 12 , or NR 14 ; inhibitors of MEK and are useful in the treatment of a variety of proliferative disease states, such as conditions related to the hyperactivity of MEK, as well as diseases modulated by the MEK cascade.

  Diarylanines，例如式（I）或式（II）中的5-酰胺取代的二芳胺，其中A是羟基、C1-6烷氧基或NR6OR7；X是OR12、NR13R12或NR14；MEK的抑制剂，在治疗各种增殖性疾病状态方面非常有用，例如与MEK过度活跃有关的疾病，以及由MEK级联调节的疾病。
• 5-AMIDE SUBSTITUTED DIARYLAMINES AS MEK INHIBITORS
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1339702A1

  公开（公告）日：2003-09-03
• US7001905B2
  申请人：——

  公开号：US7001905B2

  公开（公告）日：2006-02-21
• [EN] 5-AMIDE SUBSTITUTED DIARYLAMINES AS MEX INHIBITORS<br/>[FR] DIARYLAMINES A SUBSTITUTION 5-AMIDE, UTILISES EN TANT QU'INHIBITEUR DE KINASES ERK MITOGENES MEK
  申请人：WARNER LAMBERT CO

  公开号：WO2001068619A1

  公开（公告）日：2001-09-20

  Diarylamines, such as 5-amide substituted diarylamines of formula (I) or formula (II) wherein A is hydroxy, C1-6 alkoxy, or NR6OR7; X is OR12, NR13R12, or NR14; inhibitors of MEK and are useful in the treatment of a variety of proliferative disease states, such as conditions related to the hyperactivity of MEK, as well as diseases modulated by the MEK cascade.