3-(4-(4-methoxyphenyl) piperazine-1-yl)-N-(4-phenylthiazole-2-yl) propionamide | 1333465-89-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 3-(4-(4-methoxyphenyl) piperazine-1-yl)-N-(4-phenylthiazole-2-yl) propionamide
• 英文别名: 3-[4-(4-methoxyphenyl)piperazin-1-yl]-N-(4-phenyl-1,3-thiazol-2-yl)propanamide
• CAS: 1333465-89-6
• 化学式: C₂₃H₂₆N₄O₂S
• 分子量: 422.551
• InChiKey: PLHOBQTZAJNEBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  85.9
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• 2-AMINOTHIAZOLE DERIVATIVE, PREPARATION METHOD, AND USE
  申请人：Huazhong University of Science and Technology

  公开号：EP2682390A1

  公开（公告）日：2014-01-08

  The present invention relates to the preparation of a 2-aminothiazole derivative having a structure as formula (I) and a therapeutic effect thereof for Alzheimer's disease (AD), and a therapeutic effect thereof against transplant rejection, autoimmune diseases, ischemia-reperfusion injury, chronic inflammation response, endotoxemia, and other diseases.

  本发明涉及制备具有如下式（I）结构的2-氨基噻唑衍生物及其对阿尔茨海默病（AD）的治疗效果，以及其对移植排斥、自身免疫疾病、缺血再灌注损伤、慢性炎症反应、内毒素血症和其他疾病的治疗效果。
• 2-AMINOTHIAZOLE DERIVATIVES AND METHODS OF PREPARING AND USING THE SAME
  申请人：Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.

  公开号：US20140004155A1

  公开（公告）日：2014-01-02

  2-aminothiazole derivatives represented by formula (I), where R 1 and R 2 represent cycloalkyls, respectively; or R 1 represents a substituted aromatic group, and R 2 represents H, a C 1 -C 11 alkyl, —CH 2 Ph (benzyl), or a methyl ether including a C 1 -C 11 alkyl. R 3 is a substituent including an amino group. X represents a carbonyl or a methylene and n is an integer from 0 to 5.

  公式（I）代表的2-氨基噻唑衍生物，其中R1和R2分别代表环烷基；或者R1代表一个取代的芳香基团，R2代表H，一个C1-C11烷基，—CH2Ph（苄基），或者包括一个C1-C11烷基的甲基醚。R3是一个包含氨基的取代基。X代表一个羰基或一个亚甲基，n是一个从0到5的整数。
• PHARMACEUTICAL USE OF AMINOTHIAZOLE MYD88 SPECIFICITY INHIBITOR
  申请人：Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

  公开号：EP2682121A1

  公开（公告）日：2014-01-08

  Provided in the present invention is a pharmaceutical use of aminothiazole MyD88 specificity inhibitor, for use in preparing an immunosuppressant medicament, an anti-inflammatory medicament, a protection agent for post-ischemia reperfusion injury, and a preventative medicament for endotoxemia and sepsis.

  本发明提供了一种氨噻唑MyD88特异性抑制剂的药物用途，用于制备免疫抑制剂、抗炎药物、缺血再灌注损伤后的保护剂以及内毒素血症和败血症的预防药物。
• 2-AMINOTHIAZOLE DERIVATIVES FOR MEDICAL USE
  申请人：Huazhong University of Science and Technology

  公开号：EP3424912A1

  公开（公告）日：2019-01-09

  The present invention relates to the preparation of a 2-aminothiazole derivative having a structure as formula (I) and a therapeutic effect thereof for Alzheimer's disease (AD), and a therapeutic effect thereof against transplant rejection, autoimmune diseases, ischemia-reperfusion injury, chronic inflammation response, endotoxemia, and other diseases.

  本发明涉及一种具有式（I）结构的 2-氨基噻唑衍生物的制备及其对阿尔茨海默病（AD）的治疗效果，以及其对移植排斥、自身免疫性疾病、缺血再灌注损伤、慢性炎症反应、内毒素血症和其他疾病的治疗效果。
• US9771340B2
  申请人：——

  公开号：US9771340B2

  公开（公告）日：2017-09-26