(1-Chloro-2,2,6,6-tetramethylpiperidin-4-yl)-trimethylazanium;chloride | 1310681-28-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (1-Chloro-2,2,6,6-tetramethylpiperidin-4-yl)-trimethylazanium;chloride
• CAS: 1310681-28-7
• 化学式: C₁₂H₂₆ClN₂*Cl
• 分子量: 269.258
• InChiKey: MSQXTUDSMCJMJV-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.13
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-二甲氨基-2,2,6,6-四甲基哌啶 在 次氯酸叔丁酯 、 silver(l) oxide 作用下， 以 甲醇 、 二氯甲烷 、 水 为溶剂， 反应 2.08h， 生成 (1-Chloro-2,2,6,6-tetramethylpiperidin-4-yl)-trimethylazanium;chloride
  参考文献：
  名称：

  Novel N-chloroheterocyclic antimicrobials

  摘要：

  Antimicrobial compounds with broad-spectrum activity and minimal potential for antibiotic resistance are urgently needed. Toward this end, we prepared and investigated a novel series of N-chloroheterocycles. Of the compounds examined, the N-chloroamine series were found superior over N-chloroamide series in regards to exhibiting high antimicrobial activity, low cytotoxicity, and long-term aqueous stability. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.03.035

文献信息

• Novel N-chloroheterocyclic antimicrobials
  作者：Charles Francavilla、Eric D. Turtle、Bum Kim、Donogh J.R. O’Mahony、Timothy P. Shiau、Eddy Low、Nichole J. Alvarez、Chris E. Celeri、Louisa D’Lima、Lisa C. Friedman、Francis S. Ruado、Ping Xu、Meghan E. Zuck、Mark B. Anderson、Ramin (Ron) Najafi、Rakesh K. Jain

  DOI：10.1016/j.bmcl.2011.03.035

  日期：2011.5

  Antimicrobial compounds with broad-spectrum activity and minimal potential for antibiotic resistance are urgently needed. Toward this end, we prepared and investigated a novel series of N-chloroheterocycles. Of the compounds examined, the N-chloroamine series were found superior over N-chloroamide series in regards to exhibiting high antimicrobial activity, low cytotoxicity, and long-term aqueous stability. (C) 2011 Elsevier Ltd. All rights reserved.