(Z)-(4-cyano-2-nitrophenoxy)imino-(4-ethoxycarbonylpiperazin-1-yl)-oxidoazanium | 1309040-91-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (Z)-(4-cyano-2-nitrophenoxy)imino-(4-ethoxycarbonylpiperazin-1-yl)-oxidoazanium
• CAS: 1309040-91-2
• 化学式: C₁₄H₁₆N₆O₆
• 分子量: 364.318
• InChiKey: VZNMFCKLGVCSLI-SILNSSARSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  153
• 氢给体数：
  0
• 氢受体数：
  9

文献信息

• [EN] DIAZENIUMDIOLATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHOD OF TREATING CANCER<br/>[FR] COMPOSÉS DIAZÉNIUMDIOLATÉS, COMPOSITIONS PHARMACEUTIQUES ET PROCÉDÉ DE TRAITEMENT DU CANCER
  申请人：US HEALTH

  公开号：WO2011060215A1

  公开（公告）日：2011-05-19

  Disclosed is a method of treating cancer in a patient comprising administering to the patient an effective amount of a diazeniumdiolated (N2O2-containing) compound or a pharmaceutically acceptable salt thereof, wherein the cancer cell has an elevated level of reactive oxygen species (ROS) and/or a decreased level of one or more of PRX1, PRX6, and OGG1, compared to a normal cell of the same tissue or tissue type. An example of a diazeniumdiolated compound is Formula (I), wherein X and Q are defined herein. Also disclosed are diazeniumdiolated compounds, pharmaceutical compositions, and methods of use including enhancing the chemotherapeutic treatment of chemotherapeutic agents and high energy radiation.