N-hydroxy-2,3-dimethoxy-6-[[4-[4-(trifluoromethyl)phenyl]-1-piperazinyl]sulfonyl]benzamide | 308385-60-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: N-hydroxy-2,3-dimethoxy-6-[[4-[4-(trifluoromethyl)phenyl]-1-piperazinyl]sulfonyl]benzamide
• 英文别名: N-hydroxy-2,3-dimethoxy-6-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]sulfonylbenzamide
• CAS: 308385-60-6
• 化学式: C₂₀H₂₂F₃N₃O₆S
• 分子量: 489.472
• InChiKey: HXGPRJUKQIIYAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  117
• 氢给体数：
  2
• 氢受体数：
  11

文献信息

• Sulfonyl aryl hydroxamates and their use as matrix metalloprotease inhibitors
  申请人：——

  公开号：US20030073845A1

  公开（公告）日：2003-04-17

  This invention is directed to sulfonyl aromatic hydroxamic acid compounds and salts thereof that, inter alia, inhibit matrix metalloprotease (MMP) activity and/or aggrecanase activity. In some particularly preferred embodiments, the compound corresponds in structure to one of the following formulas: 1 wherein W 2 , the R groups, and —A—R—E—Y are described in more detail in Applicants' specification. This invention also is directed to a process that comprises administering such a compound or pharmaceutically acceptable salt thereof to a host animal having a condition associated with MMP activity.

  本发明涉及磺酰基芳基羟肟酸化合物及其盐，这些化合物在抑制基质金属蛋白酶（MMP）活性和/或聚集素酶活性方面具有作用。在一些特别优选的实施方式中，该化合物的结构符合以下公式之一：其中W2、R基团和—A—R—E—Y在申请人的说明书中有更详细的描述。本发明还涉及一种过程，该过程包括向患有与MMP活性相关的病况的宿主动物施用这种化合物或其药用可接受盐。
• USE OF SULFONYL ARYL OR HETEROARYL HYDROXAMIC ACIDS AND DERIVATIVES THEREOF AS AGGRECANASE INHIBITORS
  申请人：Pharmacia Corporation

  公开号：EP1406602A2

  公开（公告）日：2004-04-14
• SULPHONYL ARYL HYDROXAMATES AND THEIR USE AS MMP INHIBITORS
  申请人：Pharmacia Corporation

  公开号：EP1406626A2

  公开（公告）日：2004-04-14
• US6696449B2
  申请人：——

  公开号：US6696449B2

  公开（公告）日：2004-02-24
• US6683078B2
  申请人：——

  公开号：US6683078B2

  公开（公告）日：2004-01-27