(R)-8-cyclopropyl-6-(4-(2-ethoxyacetyl)-3-isopropylpiperazin-1-yl)-3,3-dimethyl-3,4-dihydro-1H-pyrano[3,4-c]pyridine-5-carbonitrile | 1416269-29-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (R)-8-cyclopropyl-6-(4-(2-ethoxyacetyl)-3-isopropylpiperazin-1-yl)-3,3-dimethyl-3,4-dihydro-1H-pyrano[3,4-c]pyridine-5-carbonitrile
• 英文别名: 8-cyclopropyl-6-[(3R)-4-(2-ethoxyacetyl)-3-propan-2-ylpiperazin-1-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile
• CAS: 1416269-29-8
• 化学式: C₂₅H₃₆N₄O₃
• 分子量: 440.586
• InChiKey: LSNHIBGUFYIJRG-NRFANRHFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  78.7
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE
  申请人：AGIOS PHARMACEUTICALS, INC

  公开号：US20170210749A1

  公开（公告）日：2017-07-27

  Provided are compounds of formula (I), wherein X, Y, Z, W, V, R 2 , R 3 and m are defined as in the description. Their pharmaceutical compositions and their uses for treating cancers are also provided.