1,3-Dimethylpiperazine dihydrochloride | 1152110-26-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1,3-Dimethylpiperazine dihydrochloride
• 英文别名: 1,3-dimethylpiperazine;dihydrochloride
• CAS: 1152110-26-3
• 化学式: C6H16Cl2N2
• 分子量: 187.11
• InChiKey: ADCWAVJWPWKDRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.75
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.3
• 氢给体数：
  3
• 氢受体数：
  2

文献信息

• [EN] PEPTIDE DEFORMYLASE INHIBITORS<br/>[FR] INHIBITEURS DE LA PEPTIDE DÉFORMYLASE
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2009061879A1

  公开（公告）日：2009-05-14

  The present invention is directed to certain 2-(alkyl)-3-[2-(5-fluoro-4-pyrimidinyl)hydrazino]-3-oxopropyl}hydroxyformamide derivatives, compositions containing them, the use of such compounds in the inhibition of bacterial peptide deformylase (PDF) activity, and in the treatment of bacterial infections. Specifically, the invention is directed to compounds of formula (I), wherein R1, R2 and R3 are defined herein and to pharmaceutically acceptable salts thereof. The compounds of this invention are bacterial peptide deformylase inhibitors and can be useful in the treatment of bacterial infections.

  本发明涉及某些2-(烷基)-3-[2-(5-氟-4-嘧啶基)肼基]-3-氧代丙基}羟甲酰胺衍生物，含有它们的组合物，以及这些化合物在抑制细菌肽变形酶（PDF）活性和治疗细菌感染中的用途。具体而言，该发明涉及式（I）的化合物，其中R1、R2和R3在此有定义，并且其药用盐。本发明的这些化合物是细菌肽变形酶抑制剂，可用于治疗细菌感染。
• [EN] COMPOUNDS AND METHODS FOR INHIBITING JAK<br/>[FR] COMPOSÉS ET PROCÉDÉS D'INHIBITION DE JAK
  申请人：ASTRAZENECA AB

  公开号：WO2017050938A1

  公开（公告）日：2017-03-30

  Disclosed are compounds of formula (I), pharmaceutical compositions comprising such compounds and methods/uses of using the same, for example, for treating a JAK-related disorder, such as cancer, cancer cachexia or an immune disorder: (I) wherein R1 is methyl or ethyl; R2 is selected from methyl, ethyl, methoxy and ethoxy; R3 is selected from hydrogen, chlorine, fluorine, bromine and methyl; R4 is selected from methyl, ethyl and -CH2OCH3; R5 and R6 are each individually methyl or hydrogen; and R7 is selected from methyl, ethyl, -(CH2)2OH and –(CH2)2OCH3, or a pharmaceutically acceptable salt thereof.

  公开的是公式(I)的化合物，包括含有这些化合物的药物组合物以及使用这些化合物的方法/用途，例如用于治疗JAK相关疾病，如癌症、癌症恶病质或免疫紊乱：(I)其中R1是甲基或乙基；R2选择自甲基、乙基、甲氧基和乙氧基；R3选择自氢、氯、氟、溴和甲基；R4选择自甲基、乙基和-CH2OCH3；R5和R6分别是甲基或氢；R7选择自甲基、乙基、-(CH2)2OH和-(CH2)2OCH3，或其药用盐。
• [EN] JAK1 SELECTIVE INHIBITORS<br/>[FR] INHIBITEURS SÉLECTIFS DE JAK1
  申请人：ASTRAZENECA AB

  公开号：WO2018134213A1

  公开（公告）日：2018-07-26

  Disclosed herein are compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein R1-R8 have any of the meanings defined herein. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I) and methods of using the same.

  本文公开了式（I）的化合物及其药用盐，其中R1-R8具有本文中定义的任何含义。还公开了包含式（I）化合物的药物组合物以及使用这些药物的方法。
• COMPOUNDS AND METHODS FOR INHIBITING JAK
  申请人：Dizal (Jiangsu) Pharmaceutical Co., Ltd.

  公开号：US20190092760A1

  公开（公告）日：2019-03-28

  Disclosed are compounds of formula (I), pharmaceutical compositions comprising such compounds and methods/uses of using the same, for example, for treating a JAK-related disorder, such as cancer, cancer cachexia or an immune disorder: wherein R 1 is methyl or ethyl; R 2 is selected from methyl, ethyl, methoxy and ethoxy; R 3 is selected from hydrogen, chlorine, fluorine, bromine and methyl; R 4 is selected from methyl, ethyl and —CH 2 OCH 3 ; R 5 and R 6 are each individually methyl or hydrogen; and R 7 is selected from methyl, ethyl, —(CH 2 ) 2 OH and —(CH 2 ) 2 OCH 3 , or a pharmaceutically acceptable salt thereof.

  本发明涉及式（I）的化合物，包括该化合物的制药组合物和使用该化合物的方法/用途，例如用于治疗与JAK有关的疾病，例如癌症、癌症恶病质或免疫紊乱，其中： R1为甲基或乙基； R2选自甲基、乙基、甲氧基和乙氧基； R3选自氢、氯、氟、溴和甲基； R4选自甲基、乙基和—CH2OCH3； R5和R6各自独立地为甲基或氢； R7选自甲基、乙基、—（CH2）2OH和—（CH2）2OCH3，或其药学上可接受的盐。
• PEPTIDE DEFORMYLASE INHIBITORS
  申请人：Qin Donghui

  公开号：US20090306066A1

  公开（公告）日：2009-12-10

  The present invention is directed to certain 2-(alkyl)-3-[2-(5-fluoro-4-pyrimidinyl)hydrazino]-3-oxopropyl}hydroxyformamide derivatives, compositions containing them, the use of such compounds in the inhibition of bacterial peptide deformylase (PDF) activity, and in the treatment of bacterial infections. Specifically, the invention is directed to compounds of formula (I): wherein R1, R2 and R3 are defined herein and to pharmaceutically acceptable salts thereof. The compounds of this invention are bacterial peptide deformylase inhibitors and can be useful in the treatment of bacterial infections.

  本发明涉及某些2-(烷基)-3-[2-(5-氟-4-嘧啶基)肼基]-3-氧代丙基}羟基甲酰胺衍生物，包含它们的组合物，这些化合物在抑制细菌肽变形酶（PDF）活性和治疗细菌感染方面的使用。具体而言，本发明涉及式（I）的化合物：其中R1，R2和R3在此定义，并且其药学上可接受的盐。本发明的化合物是细菌肽变形酶抑制剂，可用于治疗细菌感染。