trans-[Pt(NH3)2(1,6-hexanediamine)](2+) | 751450-16-5

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 英文名称: trans-[Pt(NH3)2(1,6-hexanediamine)](2+)
• CAS: 751450-16-5
• 化学式: C₆H₂₂N₄Pt
• 分子量: 345.347
• InChiKey: VERXRPGOZVMQMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  盐酸 、 trans-[PtCl(NH₃)₂(OH)]•H₂O 、 1,6-hexanediammonium dinitrate 、 丙酮 以 N,N-二甲基甲酰胺 为溶剂， 以0%的产率得到trans-[Pt(NH3)2(1,6-hexanediamine)](2+)
  参考文献：
  名称：

  Synthetic Route to Dinuclear Platinum(II) Complexes [{trans-PtCl(NH₃)₂}₂(μ-L)]²⁺ (L = Aliphatic or Heterocyclic Diamine) as Potential Antitumor Agents, Exploiting the Mutual Activation of Hydroxido Ligands and Ammonium Groups

  摘要：

  A simple and efficient method for the synthesis of potentially antitumor-active dinuclear platinum complexes of the general formula [(trans-PtCl(NH3)(2)}(2)(mu-L)]((n+2)+) (L = aliphatic or heterocyclic diamine; n = charge of L) is presented. The procedure is based on the mutual in situ activation of trans-[PtCl(OH)(NH3)(2)] and the linker L in the form of a diammoniurn salt. This synthetic pathway yielded the Farrell compound [{trans-PtCl(NH3)(2)}(2){mu-NH2(CH2)(6)NH2)]Cl-2 (BBR3005) in quantitative yield. Using the same procedure, we prepared the new pyrazolate-bridged compound [{trans-PtCl(NH3)(2)(mu-pz)]Cl, determined its X-ray structure, and tested its cytotoxicity against three wild-type and one cisplatin-resistant cell lines.

  DOI：

  10.1021/ic801251k