tert-butyl 3-(2-methoxyethylcarbamoyl)piperidine-1-carboxylate | 1016509-34-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: tert-butyl 3-(2-methoxyethylcarbamoyl)piperidine-1-carboxylate
• CAS: 1016509-34-4
• 化学式: C₁₄H₂₆N₂O₄
• 分子量: 286.371
• InChiKey: YPDPTGXTPWVVBF-UHFFFAOYSA-N

物化性质

• 沸点：
  440.0±45.0 °C(Predicted)
• 密度：
  1.084±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  67.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  tert-butyl 3-(2-methoxyethylcarbamoyl)piperidine-1-carboxylate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 N-(2-ethoxyethyl)piperidine-3-carboxamide
  参考文献：
  名称：

  [EN] COMPOSITIONS AND METHODS FOR TARGETED DEGRADATION OF PROTEINS IN A PLANT CELL
  [FR] COMPOSITIONS ET PROCÉDÉS DE DÉGRADATION CIBLÉE DE PROTÉINES DANS UNE CELLULE VÉGÉTALE

  摘要：

  Compounds, compositions, and methods for controlling the level of a target protein in a cell are described. Compounds of the disclosure include those having according to the formula PTM-L-LTM, wherein PTM is a targeting moiety that binds the target protein, L is a covalent bond or linker moiety, and LTM is a ubiquitin ligase binding moiety that binds a plant ubiquitin ligase. Additionally novel cereblon binding moieties are provided that may be used as molecular glues or in bifunctional compounds to target proteins in plants and mammals.

  公开号：

  WO2023034411A1
• 作为产物：
  描述：

  1-BOC-哌啶-3-羧酸 、 2-甲氧基乙胺 在 N,N-二异丙基乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以96.08 %的产率得到tert-butyl 3-(2-methoxyethylcarbamoyl)piperidine-1-carboxylate
  参考文献：
  名称：

  [EN] COMPOSITIONS AND METHODS FOR TARGETED DEGRADATION OF PROTEINS IN A PLANT CELL
  [FR] COMPOSITIONS ET PROCÉDÉS DE DÉGRADATION CIBLÉE DE PROTÉINES DANS UNE CELLULE VÉGÉTALE

  摘要：

  Compounds, compositions, and methods for controlling the level of a target protein in a cell are described. Compounds of the disclosure include those having according to the formula PTM-L-LTM, wherein PTM is a targeting moiety that binds the target protein, L is a covalent bond or linker moiety, and LTM is a ubiquitin ligase binding moiety that binds a plant ubiquitin ligase. Additionally novel cereblon binding moieties are provided that may be used as molecular glues or in bifunctional compounds to target proteins in plants and mammals.

  公开号：

  WO2023034411A1