(3S,4S)-3-Butyl-1-(tert-butyl-dimethyl-silanyl)-4-((E)-1-methyl-2-phenyl-vinyl)-azetidin-2-one | 241156-25-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 英文名称: (3S,4S)-3-Butyl-1-(tert-butyl-dimethyl-silanyl)-4-((E)-1-methyl-2-phenyl-vinyl)-azetidin-2-one
• CAS: 241156-25-2
• 化学式: C₂₂H₃₅NOSi
• 分子量: 357.611
• InChiKey: POFLDGIZYCFMGX-YIVRLKKSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.11
• 重原子数：
  25.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  20.31
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  (3S,4S)-3-Butyl-1-(tert-butyl-dimethyl-silanyl)-4-((E)-1-methyl-2-phenyl-vinyl)-azetidin-2-one 生成 4β-acetoxy-3β-butyl-2-azetidinone
  参考文献：
  名称：

  d-Glucosamine propanedithioacetal, an efficient chiral auxiliary in β-Lactam chemistry1Dedicated to Professor Sir Derek H. R. Barton.1

  摘要：

  The synthesis of some monocyclic beta-lactams (monobactams) by the Staudinger reaction using D-glucosamine propanedithioacetal as chiral auxiliary is reported. The influence of several radicals at C-3, C-4, and C-1' (sugar moiety) as well as other structural aspects are considered in relation to the antielastase activity. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(98)00264-8
• 作为产物：
  描述：

  在 正丁基锂 、 TEA 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 正己烷 、 二氯甲烷 、 甲苯 为溶剂， 反应 45.0h， 生成 (3S,4S)-3-Butyl-1-(tert-butyl-dimethyl-silanyl)-4-((E)-1-methyl-2-phenyl-vinyl)-azetidin-2-one
  参考文献：
  名称：

  d-Glucosamine propanedithioacetal, an efficient chiral auxiliary in β-Lactam chemistry1Dedicated to Professor Sir Derek H. R. Barton.1

  摘要：

  The synthesis of some monocyclic beta-lactams (monobactams) by the Staudinger reaction using D-glucosamine propanedithioacetal as chiral auxiliary is reported. The influence of several radicals at C-3, C-4, and C-1' (sugar moiety) as well as other structural aspects are considered in relation to the antielastase activity. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(98)00264-8