(E)-methyl 4-(3-(2,6,6-trimethylcyclohex-1-enyl)acryloyl)piperazine-1-carboxylate | 1259013-19-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (E)-methyl 4-(3-(2,6,6-trimethylcyclohex-1-enyl)acryloyl)piperazine-1-carboxylate
• 英文别名: methyl 4-[(E)-3-(2,6,6-trimethylcyclohexen-1-yl)prop-2-enoyl]piperazine-1-carboxylate
• CAS: 1259013-19-8
• 化学式: C₁₈H₂₈N₂O₃
• 分子量: 320.432
• InChiKey: PYBYHMOMXZGTDQ-BQYQJAHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  49.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE
  申请人：Bikam Pharmaceuticals, Inc.

  公开号：EP3100723B1

  公开（公告）日：2019-06-12
• Opsin-Binding Ligands, Compositions and Methods of Use
  申请人：BIKAM PHARMACEUTICALS INC.

  公开号：US20170037018A1

  公开（公告）日：2017-02-09

  Compounds and compositions of said compounds along with methods of use of compounds are disclosed for treating ophthalmic conditions related to mislocalization of opsin proteins, the misfolding of mutant opsin proteins and the production of toxic visual cycle products that accumulate in the eye. Compounds and compositions useful in the these methods, either alone or in combination with other therapeutic agents, are also described.