1-ethyl-3-{4-fluoro-5-[2-(piperazin-1-yl)pyridin-3-yl]-7-(pyridin-2-yl)-1,3-benzothiazol-2-yl}urea | 1202806-22-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-ethyl-3-{4-fluoro-5-[2-(piperazin-1-yl)pyridin-3-yl]-7-(pyridin-2-yl)-1,3-benzothiazol-2-yl}urea
• 英文别名: 1-Ethyl-3-[4-fluoro-5-(2-piperazin-1-ylpyridin-3-yl)-7-pyridin-2-yl-1,3-benzothiazol-2-yl]urea
• CAS: 1202806-22-1
• 化学式: C₂₄H₂₄FN₇OS
• 分子量: 477.565
• InChiKey: WMPPPQOYEXSVPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  123
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• BENZOTHIAZOLES AND AZA-ANALOGUES THEREOF USE AS ANTIBACTERIAL AGENTS
  申请人：Sattigeri Jitendra A.

  公开号：US20110166088A1

  公开（公告）日：2011-07-07

  The present invention provides Gyrase B and/or Topoisomerase IV par E inhibitors, which can be used as antibacterial agents. Compounds disclosed herein can be used for treating or preventing conditions caused by or contributed by gram positive, gram negative and anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Pseudomonas spp., Acenetobacter spp., Moraxalla spp., Chlamydia spp., Mycoplasma spp., Legionella spp., Ktycobacterium spp., Helicobacter, Clostridium spp., Bacteroides spp., Corynebacterium, Bacillus spp., Enterobactericeae,’ ( E. coli, Klebsiella spp., Proteus spp., etc.) or any combination thereof. Also provided, are processes for preparing compounds disclosed herein, pharmaceutical compositions containing compounds disclosed herein, and methods of treating bacterial infections. (Formula)