2-[4-(4-acetylpiperazin-1-yl)-2-methoxy-anilino]-4-imidazo[1,2-a]pyridin-3-yl-pyrimidine-5-carbonitrile | 1224705-08-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-[4-(4-acetylpiperazin-1-yl)-2-methoxy-anilino]-4-imidazo[1,2-a]pyridin-3-yl-pyrimidine-5-carbonitrile
• 英文别名: 2-[[4-(4-acetylpiperazin-1-yl)-2-methoxy-phenyl]amino]-4-imidazo[1,2-a]pyridin-3-yl-pyrimidine-5-carbonitrile；2-[4-(4-Acetylpiperazin-1-yl)-2-methoxyanilino]-4-imidazo[1,2-a]pyridin-3-ylpyrimidine-5-carbonitrile
• CAS: 1224705-08-1
• 化学式: C₂₅H₂₄N₈O₂
• 分子量: 468.518
• InChiKey: YBSJMSSCZQIUNY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  35
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  112
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• NOVEL COMPOUNDS 515
  申请人：Ducray Richard

  公开号：US20100105655A1

  公开（公告）日：2010-04-29

  There is provided novel pyrimidine derivatives of formula (I) or pharmaceutically acceptable salts thereof, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

  提供了化学式（I）的新型嘧啶衍生物或其药用盐，以及它们的制备方法、含有它们的药物组合物以及它们在治疗中的应用。
• Compounds, compositions and methods
  申请人：McDonald Andrew

  公开号：US20090005580A1

  公开（公告）日：2009-01-01

  Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.

  本发明揭示了通过调节KSP的活性来治疗细胞增殖性疾病和疾病的有用化合物。
• COMPOUNDS, COMPOSITIONS AND METHODS
  申请人：McDonald Andrew

  公开号：US20100105767A1

  公开（公告）日：2010-04-29

  Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.

  本发明揭示了通过调节KSP活性治疗细胞增殖性疾病和疾病的有用化合物。
• US7629477B2
  申请人：——

  公开号：US7629477B2

  公开（公告）日：2009-12-08
• [EN] PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS<br/>[FR] PYRAZOLO ET IMIDAZO-PYRIDINYL-PYRIMIDINAMINES UTILISÉS COMME INHIBITEURS DE LA TYROSINE KINASE IGF-1R
  申请人：ASTRAZENECA AB

  公开号：WO2010049731A1

  公开（公告）日：2010-05-06

  There is provided novel pyrimidine derivatives of formula (I) or pharmaceutically acceptable salts thereof, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.