2',3'-Dideoxy-guanosine-5'-monophosphate | 85956-71-4

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: 2',3'-Dideoxy-guanosine-5'-monophosphate
• 英文别名: [(2S,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)oxolan-2-yl]methyl dihydrogen phosphate
• CAS: 85956-71-4
• 化学式: C₁₀H₁₄N₅O₆P
• 分子量: 331.22
• InChiKey: SDMRBYKCQICSIT-NTSWFWBYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  161
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• [EN] CYCLIC DINUCLEOTIDES AS ANTICANCER AGENTS<br/>[FR] DINUCLÉOTIDES CYCLIQUES UTILISÉS EN TANT QU'AGENTS ANTICANCÉREUX
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2019046496A1

  公开（公告）日：2019-03-07

  The present invention is directed to compounds of the formula (I) wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

  本发明涉及式(I)的化合物，其中所有取代基在此定义，以及包括本发明化合物的药学上可接受的组合物，以及使用这些组合物治疗各种疾病的方法。
• [EN] BICYCLIC PEPTIDE LIGAND STING CONJUGATES AND USES THEREOF<br/>[FR] CONJUGUÉS PEPTIDE-LIGAND BICYCLIQUE ET LEURS UTILISATIONS
  申请人：BICYCLETX LTD

  公开号：WO2020165600A1

  公开（公告）日：2020-08-20

  The present invention provides compounds, compositions thereof, and methods of using the same.

  本发明提供了化合物、其组合物以及使用方法。
• Functionalization Processes and Reactants Used in Such Processes Using an Isatoic Anhydride or a Derivative Thereof, Biological Molecules Thus Treated and Kits
  申请人：Burr Arnaud

  公开号：US20130253179A1

  公开（公告）日：2013-09-26

  The present invention relates to a process of functionalising at least one ribonucleic acid (RNA) molecule which comprises the following steps: a) having at least: a binding molecule constituted by an isatoic anhydride or a derivative thereof, a group of interest, and a binding arm linking the binding molecule with the group of interest, b) reacting the anhydride function of the binding molecule with at least one hydroxyl group in: position 2′ of the ribose of one of the RNA nucleotides, and/or position(s) 2′ and/or 3′ of the ribose of the nucleotide at the 3′ terminal end of the RNA, and c) obtaining an anthranilate linking, via the binding arm, the RNA to the group of interest. The invention also relates to a functionalising reagent able to be used in such processes, a functionalised biological RNA molecule capable of being obtained by these processes and a kit for detecting a target RNA molecule comprising such a reagent. Said invention finds a preferential application in the field of in vitro diagnosis.

  本发明涉及一种功能化至少一个核糖核酸(RNA)分子的过程，包括以下步骤：a)至少具有：由异吲哚酸酐或其衍生物组成的结合分子，一个感兴趣的基团和将结合分子与感兴趣基团连接的结合臂；b)反应结合分子的酸酐官能团与RNA核苷酸中至少一个羟基反应，其中该核苷酸的核糖在2'位，和/或RNA 3'末端核苷酸的核糖在2'和/或3'位；c)通过结合臂获得一种蒽酰胺连接，将RNA与感兴趣基团连接。本发明还涉及一种可用于此类过程的功能化试剂、能够通过这些过程获得的功能化生物RNA分子以及用于检测靶RNA分子的试剂盒。本发明在体外诊断领域中具有优选应用。
• Method for nucleic acid detection by guiding through a nanopore
  申请人：Oxford Nanopore Technologies Limited

  公开号：US11085078B2

  公开（公告）日：2021-08-10

  The invention provides a method of detecting a target polynucleotide in a sample comprising: (a) contacting the sample with a guide polynucleotide that binds to a sequence in the target polynucleotide and a polynucleotide-guided effector protein, wherein the guide polynucleotide and polynucleotide-guided effector protein form a complex with any target polynucleotide present in the sample; (b) contacting the sample with a membrane comprising a transmembrane pore; (c) applying a potential to the membrane; and (d) monitoring for the presence or absence of an effect resulting from the interaction of the complex with the transmembrane pore to determine the presence or absence of the complex, thereby detecting the target polynucleotide in the sample.

  本发明提供了一种检测样品中目标多核苷酸的方法，包括(a) 将样品与与靶多核苷酸中的序列结合的引导多核苷酸和多核苷酸引导的效应蛋白接触，其中引导多核苷酸和多核苷酸引导的效应蛋白与样品中存在的任何靶多核苷酸形成复合物；(b) 将样品与包含跨膜孔的膜接触； (c) 向膜施加电位；以及 (d) 监测复合物与跨膜孔相互作用产生的效应的存在与否，以确定复合物的存在与否，从而检测样品中的靶多核苷酸。
• Methods for modulating taste receptors
  申请人：MARS, INCORPORATED

  公开号：US11185100B2

  公开（公告）日：2021-11-30

  Amino acids present in domains of an umami taste receptor are described herein, wherein the amino acids interact with at least one nucleotide derivative and/or at least one transmembrane compound that potentiates, modulates, increases, and/or enhances the activity of the umami receptor. Such compounds can be used in flavor compositions to enhance the umami taste and/or palatability of food products.

  本文描述了存在于鲜味受体结构域中的氨基酸，其中氨基酸与至少一种核苷酸衍生物和/或至少一种跨膜化合物相互作用，从而增强、调节、增加和/或提高鲜味受体的活性。此类化合物可用于调味组合物，以增强食品的鲜味和/或适口性。