(4S)-4-[4-cyano-2-(methylsulfonyl)phenyl]-6-methyl-2-oxo-3-{[4-(pyridin-2-yl)piperazin-1-yl]-carbonyl}-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidin-5-carbonitrile | 1164202-55-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (4S)-4-[4-cyano-2-(methylsulfonyl)phenyl]-6-methyl-2-oxo-3-{[4-(pyridin-2-yl)piperazin-1-yl]-carbonyl}-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidin-5-carbonitrile
• 英文别名: (4S)-4-[4-cyano-2-(methylsulfonyl)phenyl]-6-methyl-2-oxo-3-{[4-(pyridin-2-yl)piperazin-1-yl]carbonyl}-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carbonitrile；(4S)-4-[4-cyano-2-(methanesulfonyl)phenyl]-6-methyl-2-oxo-3-{[4-(pyridine-2-yl)piperazin-1-yl]carbonyl}-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-nitrile；(4S)-4-(4-cyano-2-methylsulfonylphenyl)-6-methyl-2-oxo-3-(4-pyridin-2-ylpiperazine-1-carbonyl)-1-[3-(trifluoromethyl)phenyl]-4H-pyrimidine-5-carbonitrile
• CAS: 1164202-55-4
• 化学式: C₃₁H₂₆F₃N₇O₄S
• 分子量: 649.653
• InChiKey: IWZCCVFZHONFJG-MUUNZHRXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  46
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  150
• 氢给体数：
  0
• 氢受体数：
  11

文献信息

• [DE] 4- (4-CYANO-2-THIOARYL) -DIHYDROPYRIMIDINONE UND IHRE VERWENDUNG<br/>[EN] 4-(4-CYANO-2-THIOARYL)DIHYDROPYRIMIDINONES AND USE THEREOF<br/>[FR] 4-(4-CYANO-2-THIOARYLE)-DIHYDROPYRIMIDINONE ET SON UTILISATION
  申请人：BAYER SCHERING PHARMA AG

  公开号：WO2009080199A1

  公开（公告）日：2009-07-02

  Die vorliegende Anmeldung betrifft neue 4-(4-Cyano-2-thioaryl)-dihydropyrimidm-2-on-Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung allein oder in Kombinationen zur Behandlung und/oder Prävention von Krankheiten sowie ihre Verwendung zur Herstellung von Arzneimitteln zur Behandlung und/oder Prävention von Krankheiten, insbesondere zur Behandlung und/oder Prävention von Erkrankungen der Lunge und des Herz-Kreislauf-Systems.

  这份申请涉及新的4-(4-氰基-2-硫基芳基)-二氢嘧啶-2-酮衍生物，其制备方法，其单独或与其他药物结合治疗和/或预防疾病的用途，以及其用于制造治疗和/或预防疾病的药物，特别是用于治疗和/或预防肺部和心血管系统疾病的药物。
• 4-(4-CYANO-2-THIOARYL)DIHYDROPYRIMIDINONES AND THEIR USE
  申请人：Von Nussbaum Franz

  公开号：US20140045802A1

  公开（公告）日：2014-02-13

  The present invention relates to novel 4-(4-cyano-2-thioaryl)dihydropyrimidin-2-one derivatives, to processes for their preparation, to their use alone or in combination for the treatment and/or prevention of diseases and also to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of disorders of the lung and the cardiovascular system.

  本发明涉及新型的4-(4-氰基-2-硫代芳基)二氢嘧啶-2-酮衍生物，其制备方法，其单独或联合用于治疗和/或预防疾病以及用于制备治疗和/或预防疾病的药物，特别是用于治疗和/或预防肺部和心血管系统疾病。
• 4-(4-CYANO-2-THIOARYL)DIHYDROPYRIMIDINONES AND USE THEREOF
  申请人：Bayer Intellectual Property GmbH

  公开号：US20150045344A1

  公开（公告）日：2015-02-12

  The present invention relates to novel 4-(4-cyano-2-thioaryl)dihydropyrimidin-2-one derivatives, to processes for their preparation, to their use alone or in combination for the treatment and/or prevention of diseases and also to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of disorders of the lung and the cardiovascular system.

  本发明涉及新型4-(4-氰基-2-硫基芳基)二氢嘧啶-2-酮衍生物，其制备方法，其单独或联合用于治疗和/或预防疾病以及用于制备治疗和/或预防疾病的药物，特别是用于治疗和/或预防肺和心血管系统疾病的药物。
• 4- (4-CYANO-2-THIOARYL) -DIHYDROPYRIMIDINONE UND IHRE VERWENDUNG
  申请人：Bayer Pharma Aktiengesellschaft

  公开号：EP2234985B1

  公开（公告）日：2012-03-07
• US8889700B2
  申请人：——

  公开号：US8889700B2

  公开（公告）日：2014-11-18