1-(Pentane-1-sulfonyl)piperazine | 1311569-69-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-(Pentane-1-sulfonyl)piperazine
• 英文别名: 1-pentylsulfonylpiperazine
• CAS: 1311569-69-3
• 化学式: C₉H₂₀N₂O₂S
• mdl: MFCD27920440
• 分子量: 220.33
• InChiKey: PCBSNHBZMQAWQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  57.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• N-SULFONYL THIAZOLYLPIPERAZINE DERIVATIVES AND RELATED N-SULFONYL HETEROCYCLIC DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES
  申请人：GRIFFIOEN Gerard

  公开号：US20100197703A1

  公开（公告）日：2010-08-05

  This invention provides thiazolylpiperazine derivatives, and N-sulfonyl heterocyclic derivatives including phenyl- and benzyl-thiazolylpiperidine derivatives, and pharmaceutically acceptable salts thereof, which are useful active ingredients for administration in a method for the treatment of an α-synucleopathy such as Parkinson's disease, diffuse Lewy body disease, traumatic brain injury, amyotrophic lateral sclerosis, Niemann-Pick disease, Hallervorden-Spatz syndrome, Down syndrome, neuroaxonal dystrophy, multiple system atrophy and Alzheimer's disease. This invention also provides methods for making such derivatives, and pharmaceutical compositions including such derivatives together with pharmaceutically acceptable excipients.

  该发明提供了噻唑基哌嗪衍生物，以及包括苯基和苄基噻唑基哌啶衍生物的N-磺酰杂环衍生物，以及其药学上可接受的盐，这些是用于治疗α-突触核蛋白病的有效活性成分，如帕金森病、弥漫性小体病、创伤性脑损伤、肌萎缩侧索硬化症、尼曼-匹克病、哈勒沃登-施帕茨综合征、唐氏综合征、神经轴突萎缩、多系统萎缩和阿尔茨海默病的治疗方法。该发明还提供了制备这些衍生物的方法，以及包括这些衍生物和药学上可接受的辅料的药物组合物。
• [EN] ARYL SULFONAMIDE COMPOUNDS AND USES RELATED THERETO<br/>[FR] COMPOSES DE SULFONAMIDE D'ARYLE ET PROCEDES D'UTILISATION CORRESPONDANTS
  申请人：AMGEN SF LLC

  公开号：WO2005063247A1

  公开（公告）日：2005-07-14

  The present invention provides Aryl Sulfonamide Compounds having the formula: (I); and prodrugs or pharmaceutically acceptable salts or prodrugs thereof. The Aryl Sulfonamide Compounds are useful for treating diabetes, obesity, and other diseases and disorders.

  本发明提供具有以下结构式的芳基磺酰胺化合物（I）；以及它们的前药或药学上可接受的盐或前药。这些芳基磺酰胺化合物可用于治疗糖尿病、肥胖和其他疾病和紊乱。
• Aryl sulfonamide compounds and uses related thereto
  申请人：DeGraffenreid R. Michael

  公开号：US20050277649A1

  公开（公告）日：2005-12-15

  The present invention provides Aryl Sulfonamide Compounds having the formula: and prodrugs or pharmaceutically acceptable salts or prodrugs thereof. The Aryl Sulfonamide Compounds are useful for treating diabetes, obesity, and other diseases and disorders.

  本发明提供具有以下结构式的芳基磺酰胺化合物：以及其前药或药学上可接受的盐或前药。这些芳基磺酰胺化合物可用于治疗糖尿病、肥胖症和其他疾病和紊乱。
• OXAZOLINONE DERIVATIVE HAVING INTRACELLULAR PHOSPHOLIPASE A 2? INHIBITOR ACTIVITY
  申请人：SHIONOGI & CO., LTD.

  公开号：EP0675114A1

  公开（公告）日：1995-10-04

  A compound represented by general formula (I), and having an intracellular phospholipase A₂ inhibitor activity, and a composition containing the same, wherein a and b represent each a carbon atom and the bond --¯ between the atoms a and b represents either a single or a double bond; X represents hydrogen, optionallysubstituted aryl, heteroaryl or aralkyl; Y represents hydrogen, optionally substituted aryl, aralkyl, carboxyl or a functional group related thereto; and Z represents hydrogen, optionally substituted alkyl, alkenyl, alkynyl, aralkyl, arylalkenyl, heteroarylalkyl, heteroarylalkenyl, aryloxyalkyl, aralkyloxyalkyl, arylcarbonyalkyl, arylsufonylalkyl, heteroarylsulfonylalkyl, aminoalkyl, carboxyalkyl or a functional group related thereto, alkyloxycarbonyl, aralkyloxycarbonyl, arylcarbonyl, alkylsulfonyl, arylsulfonyl or heteroarylsulfonyl; provided the case where X, Y and Z represent simultaneously hydrogen atoms is excluded.

  由通式(I)表示的具有细胞内磷脂酶A₂抑制剂活性的化合物，以及含有该化合物的组合物，其中a和b各代表一个碳原子，原子a和b之间的键--¯代表单键或双键；X代表氢、任选取代的芳基、杂芳基或芳烷基；Y代表氢、任选取代的芳基、芳烷基、羧基或与之相关的官能团；Z 代表氢、任选取代的烷基、烯基、炔基、芳烷基、芳烯基、杂芳烷基、杂芳烯基、芳氧基烷基、芳氧基烷基、芳基羰基烷基、芳基磺酰基烷基、杂芳基磺酰基烷基、氨基烷基、羧基烷基或与之相关的官能团、烷氧基羰基、芳氧基羰基、芳基羰基、烷基磺酰基、芳基磺酰基或杂芳基磺酰基；但不包括 X、Y 和 Z 同时代表氢原子的情况。
• Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof
  申请人：Northeastern University

  公开号：US10570146B2

  公开（公告）日：2020-02-25

  Disclosed are compounds that may be used to inhibit the action of fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL) or dual FAAH/MAGL. More particularly, compounds of formula II have utility in a variety of therapeutic uses such as treatment of pain, inflammation, neuropathy, or appetite disorder.

  本发明公开了可用于抑制脂肪酸酰胺水解酶（FAAH）、单酰甘油脂肪酶（MAGL）或 FAAH/MAGL 双重作用的化合物。更具体地说，式 II 的化合物 具有多种治疗用途，如治疗疼痛、炎症、神经病变或食欲不振。