[4-(Piperazin-1-yl)phenyl]methanamine | 771581-48-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: [4-(Piperazin-1-yl)phenyl]methanamine
• 英文别名: (4-piperazin-1-ylphenyl)methanamine
• CAS: 771581-48-7
• 化学式: C₁₁H₁₇N₃
• mdl: MFCD06212972
• 分子量: 191.276
• InChiKey: AMMWIBNKEHSGDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.454
• 拓扑面积：
  41.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• NOVEL MORPHOLINYL AMINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE
  申请人：F. Hoffmann-La Roche AG

  公开号：EP3623369A1

  公开（公告）日：2020-03-18

  The present invention relates to compounds of formula (I), wherein R1, R2 and R3 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

  本发明涉及式(I)的化合物，其中R1、R2和R3如本文所述，并且涉及其药用可接受的盐、对映体或二对映体，以及包括这些化合物的组合物和使用这些化合物的方法。
• [EN] THERAPEUTIC MACROLIDE COMPOUNDS AND THEIR USE<br/>[FR] COMPOSÉS DE MACROLIDES THÉRAPEUTIQUES ET UTILISATION DE CEUX-CI
  申请人：MERLION PHARMACEUTICALS PTE LT

  公开号：WO2010062265A1

  公开（公告）日：2010-06-03

  The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain macrolide compounds (for convenience, collectively referred to herein as "MC compounds"), which, inter alia, are useful in treatment of cancer. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to treat proliferative conditions such as cancer, and in the treatment of diseases and conditions that are mediated by the regulation (e.g. inhibition) of cell proliferation, optionally in combination with another agent.

  本发明一般涉及治疗化合物领域，更具体地涉及某些大环内酯化合物（为方便起见，本文统称为“MC化合物”），这些化合物在癌症治疗中有用。本发明还涉及包含这些化合物的药物组合物，以及利用这些化合物和组合物在体外和体内治疗增殖性疾病，如癌症，并在治疗通过细胞增殖调控（例如抑制）介导的疾病和病症方面的用途，可选地与另一药剂结合。
• [EN] HYDROPYRIDO[1,2-α]PYRAZINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE<br/>[FR] COMPOSÉS D'HYDROPYRIDO[1,2-ALPHA]PYRAZINE POUR LE TRAITEMENT D'UNE MALADIE AUTO-IMMUNE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2021110614A1

  公开（公告）日：2021-06-10

  The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof. The compounds act as antagonists of the toll-like receptors TLR7, TLR8 and/or TLR9 and are thus useful in the treatment of systemic lupus erythematosus (SLE) and lupus nephritis.

  本发明涉及式(I)的化合物及其药学上可接受的盐。这些化合物作为toll样受体TLR7、TLR8和/或TLR9的拮抗剂，因此在治疗系统性红斑狼疮（SLE）和狼疮性肾炎方面具有用处。
• [EN] PIPERIDINYL AMINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE<br/>[FR] COMPOSÉS DE PIPÉRIDINYL AMINE POUR LE TRAITEMENT D'UNE MALADIE AUTO-IMMUNE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2021052892A1

  公开（公告）日：2021-03-25

  The present invention relates to compounds of formula (I), wherein R1, R2, R3, R4 and R5 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

  本发明涉及公式（I）的化合物，其中R1、R2、R3、R4和R5如本文所述，并且它们的药用盐、对映体或二对映体，以及包括该化合物的组合物和使用该化合物的方法。
• Therapeutic Macrolide Compounds and Their Use
  申请人：Boyce Rustum S.

  公开号：US20110237566A1

  公开（公告）日：2011-09-29

  The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain macrolide compounds (for convenience, collectively referred to herein as “MC compounds”), which, inter alia, are useful in treatment of cancer. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to treat proliferative conditions such as cancer, and in the treatment of diseases and conditions that are mediated by the regulation (e.g. inhibition) of cell proliferation, optionally in combination with another agent.