N-(5-(3-(4-acetyl-1-piperazinyl)-6-quinoxalinyl)-2-chloro-3-pyridinyl)-4-fluorobenzenesulfonamide | 1201842-87-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: N-(5-(3-(4-acetyl-1-piperazinyl)-6-quinoxalinyl)-2-chloro-3-pyridinyl)-4-fluorobenzenesulfonamide
• 英文别名: N-[5-[3-(4-acetylpiperazin-1-yl)quinoxalin-6-yl]-2-chloropyridin-3-yl]-4-fluorobenzenesulfonamide
• CAS: 1201842-87-6
• 化学式: C₂₅H₂₂ClFN₆O₃S
• 分子量: 541.005
• InChiKey: KGNNMSGRBVKSQP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  37
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  117
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• INHIBITORS OF PI3 KINASE
  申请人：Bo Yunxin Y.

  公开号：US20110092504A1

  公开（公告）日：2011-04-21

  The present invention relates to compounds of Formula (I), or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein Q, X 1 , X 2 , R 1 and Z are as defined herein.

  本发明涉及式（I）的化合物，或其药学上可接受的盐；使用该化合物治疗疾病或病症的方法，例如癌症；以及含有该化合物的制药组合物，其中Q、X1、X2、R1和Z的定义如本文所述。
• Multifunctional inhibitors of MEK/PI3K and mTOR/MEK/PI3K biological pathways and therapeutic methods using the same
  申请人：THE REGENTS OF THE UNIVERSITY OF MICHIGAN

  公开号：US10919877B2

  公开（公告）日：2021-02-16

  Multifunctional inhibitors of mTOR, MEK, and PI3K and compositions containing the same are disclosed. Methods of using the multifunctional inhibitors in the treatment of diseases and conditions wherein inhibition of one or more of mTOR, MEK, and PI3K provides a benefit, like cancers, also are disclosed.

  本发明公开了mTOR、MEK和PI3K的多功能抑制剂以及含有这些抑制剂的组合物。还公开了使用多功能抑制剂治疗疾病和病症的方法，在这些疾病和病症中，抑制 mTOR、MEK 和 PI3K 中的一种或多种可带来益处，如癌症。
• MULTIFUNCTIONAL INHIBITORS OF MEK/PI3K AND mTOR/MEK/PI3K BIOLOGICAL PATHWAYS AND THERAPEUTIC METHODS USING THE SAME
  申请人：THE REGENTS OF THE UNIVERSITY OF MICHIGAN

  公开号：US20190224207A1

  公开（公告）日：2019-07-25

  Multifunctional inhibitors of mTOR, MEK, and PI3K and compositions containing the same are disclosed. Methods of using the multifunctional inhibitors in the treatment of diseases and conditions wherein inhibition of one or more of mTOR, MEK, and PI3K provides a benefit, like cancers, also are disclosed.
• US8415376B2
  申请人：——

  公开号：US8415376B2

  公开（公告）日：2013-04-09
• [EN] INHIBITORS OF PI3 KINASE<br/>[FR] INHIBITEURS DE LA PI3 KINASE
  申请人：AMGEN INC

  公开号：WO2009155121A2

  公开（公告）日：2009-12-23

  The present invention relates to compounds of Formula (I), or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein Q, X1, X2, R1 and Z are as defined herein.