tert-butyl 4-{5-[4-chloro-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]pyridin-2-yl}piperazine-1-carboxylate | 1257327-67-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: tert-butyl 4-{5-[4-chloro-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]pyridin-2-yl}piperazine-1-carboxylate
• 英文别名: Tert-butyl 4-[5-[4-chloro-1-(cyclopropylmethyl)benzotriazol-5-yl]pyridin-2-yl]piperazine-1-carboxylate
• CAS: 1257327-67-5
• 化学式: C₂₄H₂₉ClN₆O₂
• 分子量: 468.986
• InChiKey: IWASHTNICFDSAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  76.4
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• [EN] BIARYL BENZOTRIAZOLE DERIVATIVES<br/>[FR] DERIVES DE BENZOTRIAZOLE BIARYLE
  申请人：MERCK SHARP & DOHME

  公开号：WO2010141360A1

  公开（公告）日：2010-12-09

  The present invention is directed to biaryl benzotriazole derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.

  本发明涉及生物芳基苯并三唑衍生物，其是代谢型谷氨酸受体的增强剂，特别是mGluR2受体，并且在治疗或预防与谷氨酸功能障碍有关的神经和精神障碍以及代谢型谷氨酸受体参与的疾病方面有用。本发明还涉及包含这些化合物的制药组合物以及在预防或治疗代谢型谷氨酸受体参与的疾病方面使用这些化合物和组合物。