6-Benzyl-4-(4-(5,5-dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)thieno[2,3-d]pyrimidine | 1271738-63-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 6-Benzyl-4-(4-(5,5-dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)thieno[2,3-d]pyrimidine
• 英文别名: 6-benzyl-4-[4-(5,5-dimethyl-4H-1,3-thiazol-2-yl)piperazin-1-yl]thieno[2,3-d]pyrimidine
• CAS: 1271738-63-6
• 化学式: C₂₂H₂₅N₅S₂
• 分子量: 423.6
• InChiKey: OJAKSSMAOUQJNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  98.2
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• [EN] METHODS OF PROMOTING BETA CELL PROLIFERATION<br/>[FR] PROCÉDÉS DE PROMOTION DE LA PROLIFÉRATION DE CELLULES BÊTA
  申请人：KURA ONCOLOGY INC

  公开号：WO2018106818A1

  公开（公告）日：2018-06-14

  The present disclosure provides methods of promoting proliferation of a pancreatic cell. The methods are useful for the treatment of diabetes and other diseases characterized by impaired glucose tolerance.

  本公开提供了促进胰岛细胞增殖的方法。这些方法对于治疗糖尿病和其他以葡萄糖耐量受损为特征的疾病非常有用。
• [EN] COMPOSITIONS AND METHODS FOR TREATMENT OF LEUKEMIA<br/>[FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT DE LA LEUCÉMIE
  申请人：UNIV MICHIGAN

  公开号：WO2011029054A1

  公开（公告）日：2011-03-10

  The invention relates generally to effective treatment leukemia. In particular, the present invention provides compositions and methods to inhibit the interaction of menin with MLL and MLL-fusion oncoproteins, and well as systems and methods to screen for such compositions.

  本发明涉及有效治疗白血病的方法。具体而言，本发明提供了抑制Menin与MLL和MLL融合癌基因蛋白相互作用的组合物和方法，以及筛选这些组合物的系统和方法。
• COMPOSITIONS AND METHODS FOR TREATMENT OF LEUKEMIA
  申请人：The Regents of the University of Michigan

  公开号：EP2473054B1

  公开（公告）日：2017-06-14
• THIENOPYRIMIDINES AND USES THEREOF
  申请人：Memorial Sloan-Kettering Cancer Center

  公开号：US20170355711A1

  公开（公告）日：2017-12-14

  Described herein are thienopyrimidine compounds of Formula (I), and pharmaceutically acceptable salts, and pharmaceutical compositions thereof. Also provided are methods and kits involving the thienopyrimidine compounds or compositions for treating or preventing proliferative diseases such as cancers (e.g., brain tumors such as DIPGs) in a subject. The invention further provides an embryonic stem cell-based tumor cell model, which can be used for drug screening and disease target identification.
• US8993552B2
  申请人：——

  公开号：US8993552B2

  公开（公告）日：2015-03-31