10-amino-1-t-butyl dimethylsiloxydecane | 173606-52-5

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 10-amino-1-t-butyl dimethylsiloxydecane
• 英文别名: 10-(tert-butyldimethylsilanyloxy)decylamine；10-[Tert-butyl(dimethyl)silyl]oxydecan-1-amine
• CAS: 173606-52-5
• 化学式: C₁₆H₃₇NOSi
• 分子量: 287.561
• InChiKey: DBDWPELKMKYGKI-UHFFFAOYSA-N

物化性质

• 沸点：
  328.1±15.0 °C(Predicted)
• 密度：
  0.849±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.09
• 重原子数：
  19
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  10-amino-1-t-butyl dimethylsiloxydecane 在 四丁基氟化铵 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 10-(t-叔丁氧羰基-氨基)-1-癸醇
  参考文献：
  名称：

  Synthesis of medium ring lactams via cyclization reactions using polymer bound HOBT as catalyst

  摘要：

  The synthesis of medium ring lactams (7-, 9-, 11- and 13-membered rings) via cyclization reactions mediated by polymer bound 1-hydroxybenzotriazole (HOBT) is reported.

  DOI：

  10.1016/0040-4039(95)01977-p
• 作为产物：
  描述：

  FULVESTRANT中间体 在 lithium aluminium tetrahydride 作用下， 以 二甲基亚砜 为溶剂， 生成 10-amino-1-t-butyl dimethylsiloxydecane
  参考文献：
  名称：

  Synthesis of medium ring lactams via cyclization reactions using polymer bound HOBT as catalyst

  摘要：

  The synthesis of medium ring lactams (7-, 9-, 11- and 13-membered rings) via cyclization reactions mediated by polymer bound 1-hydroxybenzotriazole (HOBT) is reported.

  DOI：

  10.1016/0040-4039(95)01977-p

文献信息

• Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton
  申请人：BONAC CORPORATION

  公开号：US09200278B2

  公开（公告）日：2015-12-01

  Provided is a novel nucleic acid molecule that can be produced easily and efficiently and can inhibit the expression of a gene. The nucleic acid molecule is a single-stranded nucleic acid molecule including an expression inhibitory sequence that inhibits expression of a target gene. The single-stranded nucleic acid molecule includes: a region (X); a linker region (Lx); and a region (Xc). The linker region (Lx) is linked between the regions (Xc) and (Xc). The region (Xc) is complementary to the region (X). At least one of the regions (X) and (Xc) includes the expression inhibitory sequence. The linker region (Lx) has a non-nucleotide structure including at least one of a pyrrolidine skeleton and a piperidine skeleton. According to this single-stranded nucleic acid molecule, it is possible to inhibit the expression of the target gene.

  提供的是一种新型核酸分子，可以轻松高效地制备，并且可以抑制基因的表达。该核酸分子是一种包括抑制表达目标基因的表达抑制序列的单链核酸分子。该单链核酸分子包括：一个区域（X）；一个连接区域（Lx）；和一个区域（Xc）。连接区域（Lx）连接在区域（Xc）和（Xc）之间。区域（Xc）与区域（X）互补。区域（X）和（Xc）中至少一个包括表达抑制序列。连接区域（Lx）具有非核苷酸结构，包括至少一个吡咯烷骨架和一个哌啶骨架。根据这种单链核酸分子，可以抑制目标基因的表达。
• Structure–activity relationship of C5-curcuminoids and synthesis of their molecular probes thereof
  作者：Hiroyuki Yamakoshi、Hisatsugu Ohori、Chieko Kudo、Atsuko Sato、Naoki Kanoh、Chikashi Ishioka、Hiroyuki Shibata、Yoshiharu Iwabuchi

  DOI：10.1016/j.bmc.2009.12.045

  日期：2010.2

  A series of novel analogues of 1,5-bis(4-hydroxy-3-methoxyphenyl)-penta-(1E,4E)-1,4-dien-3-one (C-5-curcumin), which is a natural analogue of curcumin isolated from the rhizomes of Curcuma domestica Val. (Zingiberacea), were synthesized and evaluated for their cytotoxicities against human colon cancer cell line HCT-116 to conclude the SAR of C-5-curcuminoids for further development of their use in cancer chemotherapy: (1) Bis(arylmethylidene) acetone serves as a promising skeleton for eliciting cytotoxicity. (2) The 3-oxo-1,4-pentadiene structure is essential for eliciting cytotoxicity. (3) As for the extent of the aromatic substituents, hexasubstituted compounds exhibit strong activities, in which 3,4,5-hexasubstitution results in the highest potency. (5) The symmetry between two aryl rings is not an essential requirement for bis(arylmethylidene) acetones to elicit cytotoxicity. (6) para-Positions allows the installation of additional functional groups for use as molecular probes. By taking advantage of the SAR diagram, we have elaborated several advanced derivatives having GI(50) of single-digit micromolar potencies that will function as molecular probes to target and/or report key biomolecules interacting with curcumin and C-5-curcumin. (C) 2010 Elsevier Ltd. All rights reserved.