1-(2-ethoxyphenyl)-4-{3-[5-(4-fluorophenyl)-4-isoxazolyl]propanoyl}piperazine trifluoroacetate | 430532-46-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-(2-ethoxyphenyl)-4-{3-[5-(4-fluorophenyl)-4-isoxazolyl]propanoyl}piperazine trifluoroacetate
• 英文别名: 1-[4-(2-Ethoxyphenyl)piperazin-1-yl]-3-[5-(4-fluorophenyl)-1,2-oxazol-4-yl]propan-1-one;2,2,2-trifluoroacetic acid
• CAS: 430532-46-0
• 化学式: C₂HF₃O₂*C₂₄H₂₆FN₃O₃
• 分子量: 537.511
• InChiKey: IAALWOFLFBCWGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.79
• 重原子数：
  38
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  96.1
• 氢给体数：
  1
• 氢受体数：
  11

文献信息

• Treatment of mitochondrial diseases
  申请人：Walkinshaw Gail

  公开号：US20050065099A1

  公开（公告）日：2005-03-24

  The invention relates the method of treatment or amelioration of mitochondrial disorders such as Alzheimer's disease, Parkinson's disease, Friedreich's ataxia (FRDA), cerebellar ataxias, Leber's hereditary optic neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), Myoclonic Epilepsy with Ragged Red Fibers (MERFF), amyotrophic lateral sclerosis (ALS), motor neuron diseases, Huntington's disease, macular degeneration, and epilepsy, with chroman derivatives of Formula I or Formula II as described herein.

  这项发明涉及治疗或改善线粒体疾病，如阿尔茨海默病、帕金森病、弗里德雷希共济失调症（FRDA）、小脑共济失调、勒伯遗传性视神经病变（LHON）、线粒体肌病、脑病、乳酸中毒、中风（MELAS）、带有红色纤维的肌阵挛性癫痫（MERFF）、肌萎缩侧索硬化症（ALS）、运动神经元疾病、亨廷顿病、黄斑变性和癫痫等疾病的治疗方法，所述方法使用本文描述的FormuLA I或FormuLA II的类胡萝卜素衍生物。
• Isoxazole derivatives
  申请人：——

  公开号：US20040048908A1

  公开（公告）日：2004-03-11

  A compound represented by the formula (I) 1 wherein one of R 1 and R 2 is a hydrogen atom or a substituent and the other is an optionally substituted cyclic group; W is a bond or a divalent aliphatic hydrocarbon group; Y is a group of the formula: —OR 3 (wherein R 3 is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group or an optionally substituted acyl group) or an optionally esterified or amidated carboxyl group, or a salt thereof or a prodrug thereof has a superior insulin secretion promoting action and a hypoglycemic action and shows low toxicity. Therefore, the compound is useful as a pharmaceutical agent, particularly as an agent for the prophylaxis or treatment of diabetes and diabetic complications, and the like.

  化合物的化学式为（I）1，其中R1和R2中的一个是氢原子或取代基，另一个是可选取代的环状基团；W是键或二价脂肪基碳氢基团；Y是式子：—OR3的基团（其中R3是氢原子、可选取代的碳氢基团、可选取代的杂环基团或可选取代的酰基基团），或可选酯化或酰胺化的羧基团，或其盐或前药。该化合物具有优异的促胰岛素分泌作用和降血糖作用，并且毒性低。因此，该化合物可用作制药剂，特别是用作糖尿病和糖尿病并发症的预防或治疗剂等。
• TREATMENT OF MITOCHONDRIAL DISEASES
  申请人：Ampere Life Sciences, Inc.

  公开号：US20130267538A1

  公开（公告）日：2013-10-10

  The invention relates the method of treatment or amelioration of mitochondrial disorders such as Alzheimer's disease, Parkinson's disease, Friedreich's ataxia (FRDA), cerebellar ataxias, Leber's hereditary optic neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), Myoclonic Epilepsy with Ragged Red Fibers (MERFF), amyotrophic lateral sclerosis (ALS), motor neuron diseases, Huntington's disease, macular degeneration, and epilepsy, with chroman derivatives of Formula I or Formula II as described herein.

  本发明涉及使用式I或式II所描述的色酮衍生物的治疗或改善线粒体疾病的方法，例如阿尔茨海默病、帕金森病、弗里德雷希共济失调症（FRDA）、小脑共济失调、勒伯遗传性视神经病变（LHON）、线粒体肌病、脑病、乳酸中毒、中风（MELAS）、带红纤维的肌阵挛性癫痫（MERFF）、肌萎缩侧索硬化症（ALS）、运动神经元疾病、亨廷顿病、黄斑退化和癫痫。
• ISOXAZOLE DERIVATIVES
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1340749A1

  公开（公告）日：2003-09-03

  A compound represented by the formula (I) wherein one of R1 and R2 is a hydrogen atom or a substituent and the other is an optionally substituted cyclic group; W is a bond or a divalent aliphatic hydrocarbon group; Y is a group of the formula: -OR3 (wherein R3 is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group or an optionally substituted acyl group) or an optionally esterified or amidated carboxyl group, or a salt thereof or a prodrug thereof has a superior insulin secretion promoting action and a hypoglycemic action and shows low toxicity. Therefore, the compound is useful as a pharmaceutical agent, particularly as an agent for the prophylaxis or treatment of diabetes and diabetic complications, and the like.

  由式（I）代表的化合物 其中 R1 和 R2 中的一个是氢原子或取代基，另一个是任选取代的环状基团； W 是键或二价脂族烃基； Y 是式中的一个基团：-OR3（其中 R3 是氢原子、任选取代的烃基、任选取代的杂环基或任选取代的酰基）或任选酯化或酰胺化的羧基，或其盐或其原药具有优异的促进胰岛素分泌作用和降血糖作用，且毒性低。因此，该化合物可用作药物制剂，特别是用于预防或治疗糖尿病和糖尿病并发症等。
• US7022725B2
  申请人：——

  公开号：US7022725B2

  公开（公告）日：2006-04-04