1'-Cyclobutyl-6-(4-methylpiperazin-1-yl)spiro[3,4-dihydrochromene-2,4'-piperidine] | 1174723-69-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1'-Cyclobutyl-6-(4-methylpiperazin-1-yl)spiro[3,4-dihydrochromene-2,4'-piperidine]
• CAS: 1174723-69-3
• 化学式: C₂₂H₃₃N₃O
• 分子量: 355.524
• InChiKey: YZFRFCFZTJIFDD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  19
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• SUBSTITUTED SPIROCYCLIC PIPERIDINE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS
  申请人：Cephalon, Inc.

  公开号：EP2250176B1

  公开（公告）日：2012-08-01
• Substituted Spirocyclic Piperidine Derivatives as Histamine-3 (H3) Receptor Ligands
  申请人：Bacon Edward R.

  公开号：US20110071131A1

  公开（公告）日：2011-03-24

  The present invention provides compounds of Formula (I): their use as H 3 antagonists/inverse agonists, processes for their preparation, and pharmaceuticals compositions thereof.
• US8513232B2
  申请人：——

  公开号：US8513232B2

  公开（公告）日：2013-08-20
• [EN] SUBSTITUTED SPIROCYCLIC PIPERIDINE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS<br/>[FR] DÉRIVÉS DE PIPÉRIDINE SPIROCYCLIQUE SUBSTITUÉS EN TANT QUE LIGANDS DE RÉCEPTEUR D'HISTAMINE-3 (H3)
  申请人：CEPHALON INC

  公开号：WO2009097567A1

  公开（公告）日：2009-08-06

  The present invention provides compounds of Formula (I): their use as H3 antagonists/inverse agonists, processes for their preparation, and pharmaceuticals compositions thereof.