(2S)-1-[(3R)-4-[2-chloro-4-(2-hydroxyethoxy)phenyl]-3-phenylpiperazin-1-yl]-2-[6-(hydroxymethyl)pyridin-3-yl]propan-2-ol | 1097636-31-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (2S)-1-[(3R)-4-[2-chloro-4-(2-hydroxyethoxy)phenyl]-3-phenylpiperazin-1-yl]-2-[6-(hydroxymethyl)pyridin-3-yl]propan-2-ol
• CAS: 1097636-31-1
• 化学式: C₂₇H₃₂ClN₃O₄
• 分子量: 498.022
• InChiKey: MZGRCCRSDTZULO-RRPNLBNLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  35
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  89.3
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS
  申请人：Demong Duane Eugene

  公开号：US20100249144A1

  公开（公告）日：2010-09-30

  Compounds of Formula (I) or pharmaceutically acceptable salts, solvates, or esters thereof, are useful in treating diseases or conditions mediated by CB 1 receptors, such as metabolic syndrome and obesity, neuroinflammatory disorders, cognitive disorders and psychosis, addiction (e.g., smoking cessation), gastrointestinal disorders, and cardiovascular conditions.