4,4'-methylenebis[(4R)-2-tert-butyl-2-oxazoline] | 1242778-68-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 英文名称: 4,4'-methylenebis[(4R)-2-tert-butyl-2-oxazoline]
• 英文别名: (4R)-2-tert-butyl-4-[[(4R)-2-tert-butyl-4,5-dihydro-1,3-oxazol-4-yl]methyl]-4,5-dihydro-1,3-oxazole
• CAS: 1242778-68-2
• 化学式: C₁₅H₂₆N₂O₂
• 分子量: 266.384
• InChiKey: ZAXLRHSSOUVADG-GHMZBOCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  43.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  在 对甲基苯磺酰氟 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 乙腈 为溶剂， 反应 16.0h， 以71%的产率得到4,4'-methylenebis[(4R)-2-tert-butyl-2-oxazoline]
  参考文献：
  名称：

  Preparation, structure and catalytic activity of copper(II) complexes of novel 4,4′-BOX ligands

  摘要：

  This Letter details the synthesis of two new 4,4'-bisoxazoline (BOX) ligands. The copper(II) complex of one of the new ligands is structurally determined. The catalytic performance of the copper(II) complexes of the novel ligands, and that of our recently described phenyl AraBOX ligand in Diels-Alder reactions are reported. We have used the structural information to propose an explanation of a curious variation in the diastereoselectivity obtained in the case of one ligand complex. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.05.135

文献信息

• Preparation, structure and catalytic activity of copper(II) complexes of novel 4,4′-BOX ligands
  作者：David Frain、Fiona Kirby、Patrick McArdle、Patrick O’Leary

  DOI：10.1016/j.tetlet.2010.05.135

  日期：2010.8

  This Letter details the synthesis of two new 4,4'-bisoxazoline (BOX) ligands. The copper(II) complex of one of the new ligands is structurally determined. The catalytic performance of the copper(II) complexes of the novel ligands, and that of our recently described phenyl AraBOX ligand in Diels-Alder reactions are reported. We have used the structural information to propose an explanation of a curious variation in the diastereoselectivity obtained in the case of one ligand complex. (C) 2010 Elsevier Ltd. All rights reserved.