2,3,5,6-Tetrahydroxy-1,4-bis-methylsulfonyl-piperazin | 14508-56-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2,3,5,6-Tetrahydroxy-1,4-bis-methylsulfonyl-piperazin
• 英文别名: 1,4-bis-methanesulfonyl-piperazine-2,3,5,6-tetraol；1,4-Di(methylsulfonyl)-2,3,5,6-tetrahydroxypiperazine；1,4-bis(methylsulfonyl)piperazine-2,3,5,6-tetrol
• CAS: 14508-56-6
• 化学式: C₆H₁₄N₂O₈S₂
• 分子量: 306.318
• InChiKey: BFVIGCRESWSXNQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  172
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• [EN] SYNTHESIS OF 4,10-DINITRO-2,6,8,12-TETRAOXA-4,10-DIAZATETRACYCLO[5.5.0.0<5,9>0<3,11>]DODECANE<br/>[FR] SYNTHESE DE 4,10-DINITRO-2,6,8,12-TETRAOXA-4,10-DIAZATETRACYCLO-[5.5.0.0<5,9>0<3,11>]DODECANE
  申请人：THIOKOL CORPORATION

  公开号：WO1995004062A1

  公开（公告）日：1995-02-09

  (EN) 4,10-dinitro-2,6,8,12-tetraoxa-4,10-diazatetracyclo-[5.5.0.05,903,11]dodecane is synthesized by reacting a diacyl-2,3,5,6-tetraoxypiperazine derivative, a strong acid, and a nitrate source at a temperature above ambient temperature. The reaction product is precipitated by cooling. It may be purified by washing with methanol and/or sodium bicarbonate and by simmering in nitric acid.(FR) On synthétise 4,10-dinitro-2,6,8,12-tétraoxa,4,10-diazatétracyclo[5.5.0.05,903,11]dodécane par réaction d'un dérivé de diacyl-2,3,5,6-tétraoxypipérazine, d'un acide fort et d'une source de nitrate à une température située au-dessus de la température ambiante. Le produit réactionnel est précipité par refroidissement. On peut le purifier en le lavant avec méthanol et/ou bicarbonate de sodium et en le portant à ébullition douce dans de l'acide nitrique.

  4,10-双硝基-2,6,8,12-四氧-4,10-二氮-四环- gastricyclo-[5.5.0.05,903,11]dodecane 可通过将一种二酰基-2,3,5,6-四氧-吡咯烷衍生物、一种强酸和一种硝酸盐来源在高于室温的温度下反应制得。反应物通过冷却析晶。该产物可通过用甲醇和/或碳酸氢钠洗涤，并在硝酸中蒸馏来净化。
• US5498711A
  申请人：——

  公开号：US5498711A

  公开（公告）日：1996-03-12
• US6107483A
  申请人：——

  公开号：US6107483A

  公开（公告）日：2000-08-22
• [EN] PROCESS FOR THE LARGE-SCALE SYNTHESIS OF 4,10-DINITRO -2,6,8,12- TETRAOXA- 4,10-DIAZATETRACYCLO- [5.5.0.0<5,9>0<3,11>]- DODECANE<br/>[FR] PROCEDE DE SYNTHESE A GRANDE ECHELLE DE 4,10-DINITRO-2,6,8,12-TETRAOXA-4,10-DIAZATETRACYCL0-[5.5.0.0<5,9>0<3,11>]-DODECANE
  申请人：WARDLE ROBERT B

  公开号：WO2000009509A2

  公开（公告）日：2000-02-24

  A process for synthesizing 4,10-dinitro-2,6,8,12-tetraoxa-4,10-diazatetracyclo-[5.5.0.0?5,903,11¿]-dodecane ('TEX') involves combining at least one hexa-substituted piperazine derivative with a medium containing at least one nitronium anion source and at least one acid sufficiently strong to generate nitronium anions from the nitronium anion source. According to this invention, TEX yield is significantly improved by pre-heating the medium to 55 °C to about 70 °C and maintaining the medium from 55 °C to about 70 °C to permit the hexa-substituted piperazine derivative and nitronium anions to react and form the TEX. At least one NO¿x? scavenger is added to the medium, preferably before the addition of the hexa-substituted piperazine derivative, to increase TEX yield.