4-(2-amino-6,7,8,9-tetrahydro-benzo[4,5]furo[3,2-d]pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester | 1132690-83-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-(2-amino-6,7,8,9-tetrahydro-benzo[4,5]furo[3,2-d]pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester
• 英文别名: Tert-butyl 4-(2-amino-6,7,8,9-tetrahydro-[1]benzofuro[3,2-d]pyrimidin-4-yl)piperazine-1-carboxylate
• CAS: 1132690-83-5
• 化学式: C₁₉H₂₇N₅O₃
• 分子量: 373.455
• InChiKey: BMQVBQLFQYCSCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  97.7
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Thieno-and furo-pyrimidine modulators of the histamine H4 receptor
  申请人：Edwards James P.

  公开号：US20090075970A1

  公开（公告）日：2009-03-19

  Thieno- and furo-pyrimidine compounds are described, which are useful as H 4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H 4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H 4 receptor activity, such as inflammation.

  描述了噻吩-和呋喃-嘧啶化合物，这些化合物可用作H4受体调节剂。这些化合物可以用于制药组合物和用于调节组胺H4受体活性以及治疗由H4受体活性介导的疾病状态、紊乱和条件的方法，如炎症。
• THIENO- AND FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR
  申请人：Edwards James P.

  公开号：US20120270855A1

  公开（公告）日：2012-10-25

  Thieno- and furo-pyrimidine compounds are described, which are useful as H 4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H 4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H 4 receptor activity, such as inflammation.

  本文描述了一种噻吩和呋喃嘧啶化合物，可用作H4受体调节剂。这些化合物可用于制备药物组合物和方法，用于调节组胺H4受体活性和治疗由H4受体活性介导的疾病状态、障碍和病况，如炎症。
• THIENO- ADN FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR
  申请人：Edwards James P.

  公开号：US20120214792A1

  公开（公告）日：2012-08-23

  Thieno- and furo-pyrimidine compounds are described, which are useful as H 4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H 4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H 4 receptor activity, such as inflammation.

  本文描述了噻吩和呋喃嘧啶化合物，可用作H4受体调节剂。这些化合物可用于制备药物组合物和方法，以调节组胺H4受体活性，并用于治疗由H4受体活性介导的疾病状态、障碍和病情，例如炎症。
• THIENO-AND FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR
  申请人：Janssen Pharmaceutica, N.V.

  公开号：EP2200595A2

  公开（公告）日：2010-06-30
• US8193178B2
  申请人：——

  公开号：US8193178B2

  公开（公告）日：2012-06-05