3-(2-amino-4-methoxyphenyl)piperidin-2-one | 1258849-55-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-(2-amino-4-methoxyphenyl)piperidin-2-one
• 英文别名: 3-(2-Amino-4-methoxyphenyl)piperidin-2-one
• CAS: 1258849-55-6
• 化学式: C₁₂H₁₆N₂O₂
• 分子量: 220.271
• InChiKey: TUQDHYJNUIYJHN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5,6-dihydro-3-(4-methoxy-2-nitrophenyl)pyridin-2(1H)-one 在 palladium 10% on activated carbon 、 氢气 作用下， 以 乙醇 为溶剂， 以97%的产率得到3-(2-amino-4-methoxyphenyl)piperidin-2-one
  参考文献：
  名称：

  A Pd[0]-catalyzed Ullmann cross-coupling/reductive cyclization approach to C-3 mono-alkylated oxindoles and related compounds

  摘要：

  The Pd[0]-catalyzed Ullmann cross-coupling of o-nitrohaloarenes 1a-e with the brominated heterocycles 2a-f delivers the expected products 3a-j in good to excellent yields The reductive cyclization of such products as well as N-acyl derivatives 3k I and m has been investigated and provided the C-3 mono-substituted oxindoles 5a-d f g k and m the direct reduction products 41 and J or indole 51 (C) 2010 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tet.2010.09.042

文献信息

• A Pd[0]-catalyzed Ullmann cross-coupling/reductive cyclization approach to C-3 mono-alkylated oxindoles and related compounds
  作者：Martin G. Banwell、Matthew T. Jones、David T.J. Loong、David W. Lupton、David M. Pinkerton、Jayanta K. Ray、Anthony C. Willis

  DOI：10.1016/j.tet.2010.09.042

  日期：2010.11

  The Pd[0]-catalyzed Ullmann cross-coupling of o-nitrohaloarenes 1a-e with the brominated heterocycles 2a-f delivers the expected products 3a-j in good to excellent yields The reductive cyclization of such products as well as N-acyl derivatives 3k I and m has been investigated and provided the C-3 mono-substituted oxindoles 5a-d f g k and m the direct reduction products 41 and J or indole 51 (C) 2010 Elsevier Ltd All rights reserved