1-(tert-butyl)-5-fluoro-3,3-dimethylpiperidine | 1428989-10-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(tert-butyl)-5-fluoro-3,3-dimethylpiperidine
• 英文别名: 1-Tert-butyl-5-fluoro-3,3-dimethylpiperidine；1-tert-butyl-5-fluoro-3,3-dimethylpiperidine
• CAS: 1428989-10-9
• 化学式: C₁₁H₂₂FN
• 分子量: 187.301
• InChiKey: WRZDTKJONZNCDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-tert-butyl-2,2-dimethylpent-4-enylamine 在 N-氯代丁二酰亚胺 、 silver fluoride 、 sodium iodide 作用下， 以 二氯甲烷 、 叔丁醇 为溶剂， 反应 1.75h， 生成 1-(tert-butyl)-5-fluoro-3,3-dimethylpiperidine 、 1-tert-butyl-3-chloro-5,5-dimethylpiperidine
  参考文献：
  名称：

  An Efficient Synthesis of Fluorinated Azaheterocycles by Aminocyclization of Alkenes

  摘要：

  A general and efficient approach to important fluorinated azaheterocycles has been developed by incorporating nucleophilic fluorination into alkene difunctionalization. This intramolecular aminofluorination transformation of alkenes has been achieved via the aminocyclization of reactive unsaturated N-iodoamines, which can be generated in situ from either unsaturated N-chloramines or their amine precursors in a one-pot protocol.

  DOI：

  10.1021/ol4003866

文献信息

• An Efficient Synthesis of Fluorinated Azaheterocycles by Aminocyclization of Alkenes
  作者：Hai-Tsang Huang、Tyler C. Lacy、Barbara Błachut、Gerardo X. Ortiz、Qiu Wang

  DOI：10.1021/ol4003866

  日期：2013.4.19

  A general and efficient approach to important fluorinated azaheterocycles has been developed by incorporating nucleophilic fluorination into alkene difunctionalization. This intramolecular aminofluorination transformation of alkenes has been achieved via the aminocyclization of reactive unsaturated N-iodoamines, which can be generated in situ from either unsaturated N-chloramines or their amine precursors in a one-pot protocol.