Adenosine 5'-triphosphate potassium salt | 42373-41-1

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: Adenosine 5'-triphosphate potassium salt
• CAS: 42373-41-1
• 化学式: C10H16K2N5O13P3
• 分子量: 585.38
• InChiKey: MRTZQELCVZCIFU-IDIVVRGQSA-N

物化性质

• 溶解度：
  H2O:50 mg/mL

计算性质

• 辛醇/水分配系数(LogP)：
  -2.39
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  279
• 氢给体数：
  7
• 氢受体数：
  17

安全信息

• 危险品标志：
  Xi
• 危险类别码：
  R36/37/38

制备方法与用途

生物活性

ATP dipotassium (Adenosine 5'-triphosphate dipotassium) 是体内能量储存和代谢的重要物质，为代谢提供能量，同时在细胞中作为辅酶发挥作用。ATP dipotassium 是免疫和炎症中重要的内源性信号分子。

体外研究

ATP dipotassium (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs.
ATP dipotassium (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner.
ATP dipotassium promotes neutrophil chemotaxis in vitro.

体内研究

ATP dipotassium (50 mg/kg; i.p.) protects mice against bacterial infection in vivo.
ATP dipotassium induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo.

Animal Model:	Four-week-old Kunming mice (18-22 g)
Dosage:	50 mg/kg
Administration:	Intraperitoneal injection, before bacterial ( E. coli ) challenge
Result:	Protected mice from bacterial infection.

文献信息

• MODULATION OF SPERM MOTILITY
  申请人：Bonanni Guglielmo

  公开号：US20100222293A1

  公开（公告）日：2010-09-02

  Provided are methods of enhancing the fertility of mammalian spermatozoa involving contacting the spermatozoa with adenosine 5′-triphosphate and method of fertilization using spermatozoa treated in this way.