5-(3-Methylpiperazin-1-yl)pyridin-2-ylamine | 866620-40-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 5-(3-Methylpiperazin-1-yl)pyridin-2-ylamine
• 英文别名: 5-(3-Methyl-1-piperazinyl)-2-pyridinamine；5-(3-methylpiperazin-1-yl)pyridin-2-amine
• CAS: 866620-40-8
• 化学式: C₁₀H₁₆N₄
• 分子量: 192.264
• InChiKey: GLKGSJVNUCTAFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  54.2
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] PYRROLOPYRIMIDINE COMPOUNDS AS CDK INHIBITORS<br/>[FR] COMPOSÉS DE PYRROLOPYRIMIDINE ET LEURS UTILISATIONS
  申请人：NOVARTIS AG

  公开号：WO2010020675A1

  公开（公告）日：2010-02-25

  The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.

  所披露的化合物涉及治疗与蛋白激酶相关的疾病。此外，还需要用于治疗、预防或改善癌症、移植排斥和自身免疫疾病的一个或多个症状的化合物。更进一步，还需要使用本处提供的化合物来调节蛋白激酶活性的方法，如CDK1、CDK2、CDK4、CDK5、CDK6、CDK7、CDK8和CDK9。
• Polycyclic pyrazines as potassium ion channel modulators
  申请人：Wang Xiaodong

  公开号：US20050239800A1

  公开（公告）日：2005-10-27

  The present invention provides a genus of polycyclic pyrazines that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.

  本发明提供了一类多环吡嗪，可作为钾离子通道调节剂。该发明的调节剂可用于治疗和诊断方法。
• [EN] POLYCYCLIC PYRIMIDINES AS POTASSIUM ION CHANNEL MODULATORS<br/>[FR] PYRIMIDINES POLYCYCLIQUES UTILISES EN TANT QUE MODULATEURS DU CANAL IONIQUE DU POTASSIUM
  申请人：ICAGEN INC

  公开号：WO2005099711A1

  公开（公告）日：2005-10-27

  The present invention provides a genus of polycyclic pyrimidines that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.

  本发明提供了一类多环嘧啶，可作为钾离子通道的调节剂。该发明的调节剂在治疗和诊断方法中均有用处。
• Polycyclic thiazoles as potassium ion channel modulators
  申请人：Wang Xiaodong

  公开号：US20050227989A1

  公开（公告）日：2005-10-13

  The present invention provides a genus of polycyclic thiazoles that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.

  本发明提供了一类多环硫唑，它们可用作钾离子通道的调节剂。本发明的调节剂可用于治疗和诊断方法。
• Polycyclic Pyridines as Potassium Ion Channel Modulators
  申请人：Wang Xiaodong

  公开号：US20080108600A1

  公开（公告）日：2008-05-08

  The present invention provides a genus of polycyclic pyridines that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.

  本发明提供了一类多环吡啶，可用作钾离子通道的调节剂。本发明的调节剂在治疗和诊断方法中均有用途。