2''-(2-fluoro-phenyl)-6-(4-methyl-piperazin-1-yl)-[3,3';5',4'']terpyridine | 1354758-36-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2''-(2-fluoro-phenyl)-6-(4-methyl-piperazin-1-yl)-[3,3';5',4'']terpyridine
• 英文别名: 1-[5-[5-[2-(2-Fluorophenyl)pyridin-4-yl]pyridin-3-yl]pyridin-2-yl]-4-methylpiperazine
• CAS: 1354758-36-3
• 化学式: C₂₆H₂₄FN₅
• 分子量: 425.508
• InChiKey: RIVSQSJSJBWDFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  45.2
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• BIPYRIDYL DERIVATIVES
  申请人：Hoelzemann Guenter

  公开号：US20130102608A1

  公开（公告）日：2013-04-25

  The present invention relates to novel bipyridyl derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particularly to inhibitors of TGF-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors.

  本发明涉及公式（I）的新型双吡啶衍生物，以及在这些化合物中使用ATP消耗蛋白质如激酶的信号转导的抑制、调节和/或调控，特别是TGF-beta受体激酶的抑制剂，以及利用这些化合物治疗激酶诱导疾病，特别是治疗肿瘤的用途。
• Bipyridyl derivatives useful for the treatment of kinase-induced diseases
  申请人：Merck Patent GmbH

  公开号：EP2590946B1

  公开（公告）日：2015-02-18
• US8846931B2
  申请人：——

  公开号：US8846931B2

  公开（公告）日：2014-09-30
• US9051307B2
  申请人：——

  公开号：US9051307B2

  公开（公告）日：2015-06-09
• [EN] BIPYRIDYL DERIVATIVES USEFUL FOR THE TREATMENT OF KINASE - INDUCED DISEASES<br/>[FR] DÉRIVÉS DE BIPYRIDYL UTILES POUR LE TRAITEMENT DE MALADIES INDUITES PAR DES KINASES
  申请人：MERCK PATENT GMBH

  公开号：WO2012003912A1

  公开（公告）日：2012-01-12

  The present invention relates to novel bipyridyl derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particularly to inhibitors of TGF-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors.