8-ethyl-2-(4-methylcarbamoyl-piperazin-1-yl)-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid | 54824-97-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 8-ethyl-2-(4-methylcarbamoyl-piperazin-1-yl)-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid
• 英文别名: 8-Ethyl-2-[4-(methylcarbamoyl)piperazin-1-yl]-5-oxopyrido[2,3-d]pyrimidine-6-carboxylic acid
• CAS: 54824-97-4
• 化学式: C₁₆H₂₀N₆O₄
• 分子量: 360.373
• InChiKey: UVZPTZSDIDNROF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  119
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• INHIBITORS OF NUCLEOTIDYLTRANSFERASE SUPERFAMILY ENZYMES AS ANTIBIOTICS
  申请人：Saint Louis University

  公开号：US20200147086A1

  公开（公告）日：2020-05-14

  In one aspect, the present disclosure provides methods of treating a bacterial infection using an inhibitor of the nucleotidyltransferase superfamily enzyme. In some embodiments, the compounds have one of the following formulas (I), (II), (III), or (IV) wherein R 1 , R 2 , and R 3 are as defined herein or a pharmaceutically acceptable salt thereof. The compounds may be used to treat a bacterial infection including an infection of Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa , and Enterobacter species.